Alphabet Soup

Question 1

IL-1 (+IL-1B)

Answer 1

Pro-inflammatory cytokine produced by sentinel cells, upregulate expression of selectins, IL-1B produced by inflammasome and involved in gout

Question 2

IL-2

Answer 2

activates macrophages by CD25 receptor

Question 3

IL-4

Answer 3

stimulates healing processes

Question 4

IL-5

Answer 4

eotaxin, (recruits eosinophils)

Question 5

IL-6

Answer 5

Pro-inflammatory cytokine produced by sentinel cells, promotes B cell differentiation

Question 6

IL-8

Answer 6

recruits neutrophils

Question 7

IL-10

Answer 7

stimulates healing processes, anti-inflammatory cytokine

Question 8

IL-13

Answer 8

stimulates healing processes

Question 9

IL-18

Answer 9

inflammatory mediator secreted by inflammasome

Question 10

TNF

Answer 10

Pro-inflammatory cytokine produced by sentinel cells, cytotoxic, upregulate expression of selectins

Question 11

TGF-beta

Answer 11

anti-inflammatory cytokine

Question 12

IFN-gamma

Answer 12

produced by NK cells and Th1 cells to activate macrophages, involved in granulomas

Question 13

TLR2

Answer 13

Recognizes lipoproteins, activates macrophages

Question 14

TLR4

Answer 14

Recognizes LPS, activates macrophages

Question 15

TLR 7/8

Answer 15

stimulated by imiquimod in horses, immune response to equine sarcoids

Question 16

TLR9

Answer 16

Recognizes CpG DNA

Question 17

CD4

Answer 17

receptor on the surface of Th cells, binds MHC-II

Question 18

CD8

Answer 18

receptor on the surface of Tc cells, binds MHC-I

Question 19

CD14

Answer 19

involved in binding LPS to TLR4

Question 20

CD18

Answer 20

integrin that is affected in leukocyte adhesion deficiency

Question 21

CD25

Answer 21

receptors on Treg cells and macrophages for IL-2

Question 22

CD46

Answer 22

aka MCP, displaces C2a from C3 convertase

Question 23

CD59

Answer 23

protects host cell against MAC formation (blocks C9)

Question 24

CD71

Answer 24

receptor for transferrin on macrophages

Question 25

CD79

Answer 25

heterodimeric signaling portion of BCR complex

Question 26

I-CAM

Answer 26

inter-cellular adhesion molecules (integrins), active during stable adhesion phase of extravasation

Question 27

LBP, MD-2

Answer 27

involved in binding LPS to TLR4

Question 28

Fibrinogen and SAA

Answer 28

acute phase proteins produced by liver that indicate presence of inflammation, useful to track progress of treatment

Question 29

J chain

Answer 29

binds IgM pentamer and secretory IgA dimer

Question 30

FcRn

Answer 30

binds IgG within endosomes, recycles antibody back to cytoplasm

Question 31

Fc-epsilon

Answer 31

binds IgE with unusually high affinity BEFORE it has bound an antigen

Question 32

Fc-gamma

Answer 32

used by NK cells to induce apoptosis of antibody coated tumor cells

Question 33

Th1

Answer 33

Th cell activates macrophages

Question 34

Th2

Answer 34

Th cell generates inflammatory response

Question 35

Th17

Answer 35

Th cell stimulates neutrophil response

Question 36

Tfh

Answer 36

Th cell stimulates antibody production from B cells

Question 37

Treg

Answer 37

Th cell regulates immune response

Question 38

C3a

Answer 38

induces inflammation and recruits phagocytic cells, anaphylatoxin stimulates release of histamine

Question 39

C5a

Answer 39

induces inflammation and recruits phagocytic cells, also regulates phagocytosis, acts on neutrophils to increase adherence, anaphylatoxin stimulates release of histamine

Question 40

TCR

Answer 40

binds linear peptides displayed by MHC molecules

Question 41

BCR

Answer 41

binds specific antigens

Question 42

MHC-I

Answer 42

made by all nucleated cells when invaded, presents to Tc cells

Question 43

MHC-II

Answer 43

made by APCs, presents to Th cells

Question 44

NLR/RLR

Answer 44

NOD-like receptors and rig-like receptors are cytosolic PRRs that detect bacteria and viruses inside cells, trigger inflammasomes