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Flashcards in aminoglycosides Deck (10):
1

aminoglycosides - mechainsm

bactericidal
binds to 30 S ribosome and prevents protein synthesis
mRNA misreading, polysome break up
usually given with penicillins

should be bacteriostatic but something in the mechanism makes it bactericidal

2

streptomycin - use

treat tuberculosis
streptococci/enterocicci
plague, brucellosis, tularemia

3

streptomycin - toxicity

hypersensitivy
vestibular reactions
least nephrotoxic

4

gentamicin - use

work horse
first choice for gram -
enterobacter
proteus
pseudo aeruingnosa
strep facaelis
listeria (meningitis)

5

tobramycin - use

gram -
enterobacter
proteus
pseudo aeruingnosa***
strep facaelis
listeria (meningitis)

attacked by 7 resistance enzymes

6

kanamycin - use

oral only
limited use due to resistance
suppress intestinal flora before surgery

treats gram - by klebsiella, enterobacter, proteus, e coli

7

amikacin - use

semisynthetic dreiv of kanamycin that has engineered resistence to most of the resistance enzymes
more expensive

serratia, proteus, pseudo aeruginosa, klebsiella, enterobacter, e coli

resistnat - actinetbacter, providencia, flavo (rare )

8

neomycin - use

broad spectrum against gram +/-
too toxic for systemic use
topical use for burns, wounds, ulcers

9

netilmicin - use

broad spectrum - gram - bacilli, aerobic
resistant to enzyme inactivation

10

aminoglycosides - toxicity

nephrotixicity
ototoxicity
neuromuscular blockade