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Flashcards in Miscellaneous Drugs Deck (58):
1

macrolides - mechanism

50s ribosome
bacteriostatic

2

macrolides - side effects

GI intolerance

3

macrolides - not effective against:

enterococcus sp
staphylococcus sp

4

macrolides - excretion

renal

5

which macrolide interferes with P450

clarithromycin

6

which macrolide requires dose adjustment with low CrCl

clarithromycin

7

clindamycin - mechanism

50S ribosome
bacteriostatic

8

clidamycin - side effects

AAMPC
diarrhea

9

clindamycin - not effective against

enterococcus

10

synercid (quinupristin/dalfopristin) - mechanism

binds 50S ribosome
BC and BS

11

synercid - side effects

arthralgias
inhibits cyp3A4

12

synercid reserved for:

MRSA, VRE

13

synercid - not effective against

enterococcus faecalis

14

what drugs in the miscellaneous category act on the ribosome?

macrolids (clarithromycin, azithromycin)
clindamycin
synercid (quinupristin/dalfopristin)
linezolid

15

what drugs in the miscellaneous category act on the cytoplasmic membrane

polymyxin
daptomycin

16

what drugs in the miscellaneous category act on the cell wall

bacitracin
vancomycin

17

linezolid - mechanism

prevent formation of 70S ribosome - unique binding
BS/BC

18

linezolid - side effects

headaches
rashes
serotonin syndrome

19

linezolid - use:

reserved as drug of last resort
meningitis (70% CSF)
VRE, MRSA, MRSE

20

polymyxin B - mechanism

cation detergent
BC/BS

21

polymyxin B - side effects

nephrotoxicity if IV

22

polymyxin B - excretion

renal
dosage adjustment with impairment

23

bacitracin - mechanism

inhibits cell wall synthesis
BC

24

bacitracin - side effects

nephrotoxicity if IV

25

vancomycin - mechanism

inhibits cell wall syntheiss
BC

26

vancomycin - side effects

nephrotoxicity; increased with aminoglycosides

27

vancomycin - administration

IV, oral (poor absorption from GI)
never IM

28

vancomycin - used for:

usually reserved for MRSA, MRSE

29

vancomycin - not used for

gram negative, anaerobes, VRE

30

daptomycin - mechanism

depolarizes membrane - disrupts membrane potential, oxphos
BC

31

daptomycin - used in:

MRSA
VRE

32

daptomycin - side effects

constipation nausea headache
inactivated by calcium in surfactant (in lung)

33

daptomycin - excretion

renal
dosage adjustment required in impairment

34

daptomycin - not useful for

anaerobes, gram -
pneumonia

35

what drugs need dosage to be adjusted with renal impairment?

clarithryomycin
polymyxin
vancomycin
daptomycin

36

what drugs cause neuromuscular blockade (NPMR)

polymyxin
bacitracin
clindamycin

37

which drugs are poorly absorbed orally

vancomycin
synercid
polymyxinB
daptomycin

38

which miscellaneous drug is only given IV

synercid

39

which miscellaneous drugs are BS only?

macrolids (clarithrymycin, azithromycin)
clindamycin

40

which drugs distribute well to CNS

linezolid
bacitracin
vancomycin (with inflammed meninges)

41

nephrotoxicity a risk when given parenterally:

bacitracin
polymyxin

42

which drugs work against gram + aerobes

macrolides
clindamycin
synercid
bacitracin
vancomycin
daptomycin

43

which drug works against gram - aerobes?

polymyxin

44

which drug works against anaerobes, + and -?

clindamycin

45

which drug is good for CAPs?

macrolides
- work against s pneumoniae, some gram - including h. influenzae, and bordetella sp

46

which drug is associated with increased incidence of c. diff colitis?

clindamycin

47

which drug is associated with serotonin syndrome when taken with SSRIs

linezoid

48

which drugs don't work against enterococcus?

macrolides
clindamycin
E. facaelis resistant to synercid

49

which drugs dont work against s aureus?

macrolides
polymyxinB

50

which drugs are used against MRSA, VRE

linezolid
synercid
daptomycin

51

what drug is reserved to treat MRSA/MRSE

vancomycin

clindamycin also effective against MRSA/MSSA

52

poor oral absorption

VPSDB

very poor stomach duodenum bowel

53

renal impairment requries dose adjustment

DPVC

dialysis provokes value clarification

54

CNS penetration (goes to your head)

LBV

little bit vain

55

MRSA

CdV

CoulD be Vorse

56

MRSA and VRE=

last drug soluton

57

Nephrotoxicity

BP

British Petroleum

58

NPMR (neuromuscular blockage)

PBCd

Public Broad CDasting