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Flashcards in quinolones Deck (11):
1

mechanism of quinolones

binds to DNA gyrase and topo IV (not found in mammalian cells)
blocks DNA rep

bactericidal

2

first generation quinolone

nalidixic acid

3

naldixic acid - use

limited to treatment of UTIs
narrow gram - spectrum

4

second generation quinolones

ciprofloxacin
norfloxacin

5

second gen (ciprofloxacin, norfloxacin) - use

increased gram - activity, some gram +
chlamydia, mycoplasma (bacteria without cell wall)
UTI
GI
STD
skin infections
gram - osteomyelitis
S pnemonae resistance

6

third gen quinolones

levofloxacin

7

levofloxacin - use

broader gram + - spectrum
chlamydia, mycoplasm, strep pneumonae, meningitis by H influenzae
infection of sinuses, skin, lungs, ear, airway, bone, joints

communciable bacterial infections

8

fourth gen quinolone

moxifloxacin

9

moxifloxacin - use

added anaerobic coverage
poor pseudomonas coverage
NOT used for UTI, not excreted in urine

10

which classes of drugs cant be taken with antacids or milk

tetracyclines
quinolones

11

quinolones - toxicity

gi toxicity
CNS tox
phototoxicity
arthralgias
tendonitis
potentiates warfarin
QT interval prolongation