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Flashcards in sulfonamides Deck (13):
1

sulfonamides are primarily used for:

UTIs

2

name the sulfonamides:

sulfadiazine
silver sulfadizine
sulfisoxazole
sulfamethoxazole
sulfacetamide

sulfamethoxazole + trimethoprim

3

mechanism of sulfonamides

bacteriostatic

reversible inhibitor of folic acid synthesis
(dihydropteroate synthethase inhibtor)

4

sulfadiazine treats

UTI

5

silver sulfadizine - use

topic antibiotic for wound management

6

which sulfonamide is used for ear infections

sulfisoxazole

7

which sulfonamide is used for eye infections (drops) and rosaciae (topical)

sulfacetamide

8

trimethoprim + sulfamethoxazole - mechanism

inhibit folic acid synthesis

trimethoprim - inhibits dihydrofolate reductase
sulfamethoxazole - inhibits dihydropteroate synthetase
-two sequential steps in the production of folic acid

bacteriostatic?

9

sulfonamides - side efects

stephen johnsons syndrom (hypersensitivty)
renal crystalluria
bone marrow suppression
hemolytic anemia
protein binding drug interactions

10

which sulfonamide has the least risk for renal crystalluria

sulfisoxazole

11

* chloramphenicol - mechainsm

bacteriostatic
binds 50S ribosome

12

* chloramphenicol - use

broad spectrum against gram - microorganisms
rickettsiae

13

* chloramphenicol - toxicity

gray baby syndrome
hematological toxicity, bone marrow suppresion
hypersensitivity reactions