Aminoglycosides

Question 1

Amino glycosides examples

Answer 1

Gentamicin
Amikacin

Question 2

Gentamicin spectrum of activity

Answer 2

activity against many
aerobic gram-negative
bacteria and staphylococci.

PSEUDOMONAS
E.COLI

Question 3

Gentamicin indications

Answer 3

Sepsis
Bone infections
Endocarditis
Pneumonia
UTI

Question 4

Gentamicin MOA

Answer 4

Bactericidal by irreversibly
binding to ribosomes
inhibiting protein synthesis;
fissure result which
enhances antibiotic uptake
as well as leakage of cell
contents.

Question 5

SE of gentamicin

Answer 5

Impair neuromuscular transmission
Irrervisible ototoxicity
Nephrotoxicity
Electrolyte disturbances

Question 6

CI/cautions of gentamicin

Answer 6

Caution in patients with muscular weakness (Myasthenia graves)
Avoid with ototoxic and nephrotoxic drugs

Question 7

Gentamicin monitoring

Answer 7

Renal function
Auditory and vestibular function
Serum conc in elderly

Question 8

Gentamicin MHRA warnings

Answer 8

Potential for histamine related adverse drug reactions in some batches
Increase risk of deafness in patients with mitochondrial mutations