Glycopeptides

Question 1

glycopeptides examples

Answer 1

Vancomycin
Teicoplanin

Question 2

Vancomycin MOA

Answer 2

works by inhibiting growth
and the cross-linking of
peptidoglycan chains,
therefore inhibiting the cell
wall of gram-positive
bacteria.

Question 3

Vancomycin spectrum of activity

Answer 3

Specific activity against aerobic and anaerobic gram positive bacteria. Not gram negative as lipopolysacrradie

Question 4

Vancomycin indications

Answer 4

C diff
MRSA INFECTIONS

Question 5

Vancomycin SE

Answer 5

Nephrotoxic
Ototoxic (tinnitus and hearing loss)
Thrombocytopenia
Neutropenia
Flushing of upper body (vanc infusion reaction)
Skin rashes (potentially SJS)

Question 6

Therapeutic range of vancomycin

Answer 6

trough
10 to 15mg/L
(15 to 20mg/L for
endocarditis or less
sensitive strains of
methicillin-resistant
Staphylococcus aureus or
complicated infections
caused by S. aureus)

Question 7

Vancomycin monitoring requirements

Answer 7

Blood counts
Hepatic and renal function
Urinalysis
Plasma levels
Auditory function in elderly

Question 8

Teicoplanin indications

Answer 8

Septicemia
Endocarditis
Bone and joint infections

Question 9

Teicoplanin spectrum of activity

Answer 9

bactericidal activity against
aerobic and anaerobic
Gram-positive bacteria
including multi-resistant
staphylococci.

Question 10

Teicoplanin SE

Answer 10

Same as Vanc