Aminoglycosides Flashcards Preview

Pharmacology > Aminoglycosides > Flashcards

Flashcards in Aminoglycosides Deck (14)
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0
Q

How are aminoycosides best absorbed?

A

Parent real injection

1
Q

What is the mechanism of action in amino glycosides?

A

Inhibit bacterial protien synthesis by attaching to the bacterial ribosomes

2
Q

Where are aminoglycosides not well absorbed?

A

GI or uterus

3
Q

How does aminoglycosides absorb?

A

Hydrophilic at physiologic pH

4
Q

What tissues do aminoglycosides not penetrate well?

A

CNS, eye, prostate gland

5
Q

Where does aminoglycosides accumulate and what happens?

A

Inner ear and kidneys. Can cause deafness and kidney disease

6
Q

How are aminoglycosides eliminated?

A

Kidneys

7
Q

What are aminoglycosides widely effective against?

A

G-

8
Q

What is aminoglycosides not effective against?

A

Anaerobic bacteria

9
Q

What can dehydration cause with aminoglycosides?

A

Higher concentrations

10
Q

Are aminoglocosides bacteriocidal or bacteriostatic?

A

Bacteriocidal

11
Q

What types of animals should you use caution with aminoglycosides?

A

Renal disease or poor renal diffusion

12
Q

What four aminoglycosides should not be mixed with penicillin?

A

Gentamicin, amikacin, kanamycin, tones mucin

13
Q

What are aminoglycosides inactivated by?

A

Cellular debris, wound must be flushed