Aminoglycosides

Question 1

Aminoglycosides

Answer 1

Gentamicin, Tobramycin, Amikacin

Question 2

AG Spectrum

Answer 2

Good: GNs(Pseudo, Acinetobacter)

Mod in combo with beta-lactam or glycopeptide: GP cocci

Question 3

Gentamicin/Tobramycin Dose

Answer 3

IV/IM, MDD: 1-2.5 mg/kg/dose q8-12h, Extended: 5-7 mg/kg

Question 4

Amikacin Dose

Answer 4

IV/IM, MDD: 5-7.5 mg/kg q8-12h, Extended: 15-20 mg/kg

Question 5

AG Kinetics

Answer 5

Conc dependent bactericidal activity

Question 6

EID Renal

Answer 6

60 over: q24h, 40-60: q36h, 20-40: q48h

Question 7

EID Contraindications

Answer 7

Severe burn victim, CF, pregnancy, neonates, peds, ascitesm HD

Question 8

AG Dosing Weight

Answer 8

Base on IBW or AdjBM

Question 9

AG Ke

Answer 9

Ke = 0.00293 x CrCl + 0.014

Question 10

AG Vd

Answer 10

Vd = 0.23 L/kg x IBW

Question 11

Gent/Tobra MDD Peak

Answer 11

Draw 30 min after infusion ends, Cmax = 5-10 mcg/mL

Question 12

Gent/Tobra MDD Trough

Answer 12

Draw 30 min before dose, Cmax = 1 mcg/mL

Question 13

MDD Interval

Answer 13

Interval = ((ln [Cmax/Cmin])/Ke) + t(inf)

Question 14

MDD Dose

Answer 14

MD = [Cmax x (Vd x Ke) x (1-e -Ke x Tint)]/ (1-e -Ke x tinf)

Question 15

MDD Loading Dose

Answer 15

LD = Cmax (Vd x Ke)/(1-e -Ket)

Question 16

Amikacin MDD Peak

Answer 16

Draw 30 min after infusion ends, Cmax = 15-30 mcg/mL

Question 17

Amikacin MDD Trough

Answer 17

Draw 30 min before dose, Cmax = 3-4 mcg/mL

Question 18

MDD Steady State

Answer 18

3-4 half lives

Question 19

Gent/Tobra In AFR

Answer 19

Redose at 1 mg/mg once level below 2.5 mcg/mL

Question 20

AG and HD

Answer 20

HD removes about 50% of AG conc

Question 21

AG EID Levels

Answer 21

6-14 hr dose checks against Nomogram