amiodarone Flashcards
1
Q
main indications
A
-arrythmias when other drugs are ineffective
- A Fib and flutter
- V FIB or pulseless ventricular tachycardia
2
Q
mechanism of action
A
- Class III anti-arrhythmic - blocks K+channels therefore prolonging the refractory period
- Also effective at blocking Na+, having a high affinity for inactivated channels
- Anti-adrenergic effects by non-competitively blocking α and β receptors
- Also has weak Ca2+blocking effect
- Slows down the sinus rate and AV conduction, and slightly prolongs the QT interval
3
Q
contraindications and cautions
A
- Contraindicated in heart block, bradycardia, thyroid dysfunction and hypokalaemia
- Avoid injection in cardiomyopathy; congestive heart failure; severe respiratory or heart failure
4
Q
adverse effects
A
- Corneal microdeposits
- Hypokalaemia
- Hepatic disorders
- Hyperthyroidism
- Respiratory disorders
- Phototoxic → skin reactions
5
Q
administration
A
PO or IV
