Bile binding resins

Question 1

main indications

Answer 1

hyperlipidaemia

Question 2

mechanism of action

Answer 2

• Cause the excretion of bile salts, resulting in more cholesterol to be converted to bile salts by interrupting enterohepatic recycling
• Prevent the reabsorption of bile salts (normally nearly all are reabsorbed)
• Causes decreased absorption of TAGs and increased LDL receptor expression

Question 3

contraindications and cautions

Answer 3

Can interfere with the absorption of fat-soluble vitamins - vitamin supplements may be required if treatment is prolonged

Question 4

administration

Answer 4

PO

Question 5

adverse effects

Answer 5

GI tract irritation