heparin Flashcards
1
Q
main indications
A
- DVT
- PE
- Unstable angina
2
Q
mechanism of action
A
- Antithrombin III inhibits coagulation by neutralizing the active clotting factors (serine proteases)
- Heparin increases the affinity of antithrombin III for clotting factors to greatly increase their rate of clotting factor inactivation
3
Q
contraindications and cautions
A
Caution in hepatic/renal impairment
4
Q
adverse effects
A
- Haemorrhage - discontinue drug, administer protamine sulfate IV if necessary
- Heparin-induced thrombocytopenia
- Hyperkalaemia
5
Q
administration
A
IV or SC
