Analgesic

Question 1

Non opioid analgesic

Answer 1

Paracetamol and metamizol

Question 2

Opioid receptor agonists

Answer 2

Morphine,codeine, Fentanyl, Tramadol, Buprenorphine

Question 3

Coanalgesic are

Answer 3

Antiepileptic, antidepressants and central alpha adrenoreceptor agonist

Question 4

Serotonin receptor agonist analgesic

Answer 4

Sumatriptan

Question 5

Opioid receptor antagonist

Answer 5

Naloxone

Question 6

NSAIDS

Answer 6

Diclofenac and ibuprofen

Question 7

CGRP receptor antagonist analgesic

Answer 7

Erenumab

Question 8

CGRP antagonist

Answer 8

Galcanezumab

Question 9

Nociceptive pain

Answer 9

Damage to tissues other than nerves

Question 10

Neuropathic pain cause

Answer 10

by damage of somatosensory nerve system or disease

Question 11

Neuropathic pain characteristic

Answer 11

Excessive sensitization of neurons and formation of ectopic signals foci

Question 12

Ectopic signal foci is caused by

Answer 12

Over expression of sodium channels

Question 13

In nociceptive system they finally connect to

Answer 13

Spinothalamic and spinomedullary tract neurons

Question 14

Anti nociceptive regulation is

Answer 14

Downward modulation

Question 15

Stimulation of peraqueductive efferent tract leads to release of

Answer 15

Serotonin,NE and Encephalins,which block afferent pain impulse by substance p and glutamate

Question 16

Three types of opioid receptor are

Answer 16

Mu,delta and kappa

Question 17

MOA of opioid

Answer 17

Presynaptic calcium channel blockage and post synaptic potassium channel opening (hyperpolarization

Question 18

Spinal analgesia reduce

Answer 18

afferent fiber signal transduction

Question 19

Morphine acts on

Answer 19

Mu ,delta and kappa receptor and has analgesic and sedative effect

Question 20

Morphine use

Answer 20

Traumatic pain, postoperative pain, tumor induced pain

Question 21

Codeine

Answer 21

Weak mu receptor agonist, analgesic and sedative effect

Question 22

Codeine use

Answer 22

Moderate intensity pain

Question 23

Fentanyl

Answer 23

Mu and delta receptor agonists, partial kappa agonist, analgesic effect stronger than morphine and sedative effect (lipophilic,short acting)

Question 24

Fentanyl ise

Answer 24

Tumor pain

Question 25

Tramadol

Answer 25

Weak mu receptor agonist and analgesic effect enhanced by SNRI and SSRI,has analgesic and sedative effect

Question 26

Tramadol use

Answer 26

Moderate intensity pain

Question 27

Buprenorphine

Answer 27

Partial agonist of my and antagonist of kappa, analgesic and sedative effect

Question 28

Buprenorphine use

Answer 28

Abstinence of potential opioid receptor agonists and severe to moderate pain

Question 29

Side effects of opiods

Answer 29

Respiratory depression, nausea vomiting, pupillary constriction, suppression of cough, constipation, urinary retention, increase tone of sphincter of oddi,bradycardia, hypotension,itching

Question 30

Main side effects of opiods

Answer 30

Euphoria, addiction, abstinence, tolerance

Question 31

Symptoms triad of opiods receptor agonists toxicology

Answer 31

Respiratory depression,miosis,coma

Question 32

Naloxone action

Answer 32

On my kappa and delta,iV, short acting

Question 33

Naloxone

Answer 33

Reduce respiratory depression, limit abuse of buprenorphine,reduce risk of opioid induced constipation

Question 34

Paracetamol is

Answer 34

Prostaglandin H2 synthetase inhibitor,inhibition of COX 2 and COX 3,Inhibition of prostaglandin synthesis centrally

Question 35

Prostaglandin H2 synthetase is same as

Answer 35

Cyclooxygenase

Question 36

Paracetamol has

Answer 36

Antipyretic and analgesic effect with slight anti inflammatory effect

Question 37

Paracetamol use

Answer 37

Short term treatment of moderate intensity postoperative pain, symptomatic treatment of mild to moderate pain,fever

Question 38

SE of paracetamol

Answer 38

Liver failure, encephalopathy,coma

Question 39

Ethnol increase

Answer 39

Paracetamol toxicity

Question 40

Antidote for paracetamol toxicity

Answer 40

Acetylcysteine iv

Question 41

Metamizol effect

Answer 41

Inhibition of COX,antispasmodic effect

Question 42

SE of metamizol

Answer 42

Agranulocytosis

Question 43

Metamizol use

Answer 43

Severe to moderate intensity postoperative and post trauma pain,severe moderate intensity acute pain,fever

Question 44

Migrane

Answer 44

Unilateral, pulsating pain in forehead and temples.1-6 attack per month

Question 45

Sumatriptan is used for

Answer 45

Treatment of migraine attacks

Question 46

Galcanezumab and erenumab use

Answer 46

Migraine attack prophylaxis

Question 47

Clonidine uae

Answer 47

Adjuvant opioid therapy

Question 48

Carbamazepine use

Answer 48

N.trigeminus neuralgia

Question 49

Valproic acid use

Answer 49

Prevention of migraine attack

Question 50

Gabapentin use

Answer 50

Post herpetic neuralgia

Question 51

Amitriptyline ise

Answer 51

Fibromyalgia

Question 52

Amitriptyline ise

Answer 52

Fibromyalgia