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Pharma 3 > Pharma Collq3 > Flashcards

Pharma Collq3 Flashcards

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1
Q

Non opioid analgesic are

A

Paracetamol and metamizol

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2
Q

Opioid receptor agonists are

A

Codaine, fentanyl, morphine, tramadol,buprenorphine

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3
Q

Coanalgesics

A

Anti epileptic drugs, antidepressants, central Aalpha adrenoreceptor agonist

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4
Q

5HT receptor agonists

A

Sumatriptan

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5
Q

Opioid receptor antagonist

A

Naloxone

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6
Q

NSAIDS

A

Ibuprofen and dickofenac

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7
Q

CGRP receptor antagonist

A

Erenumab

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8
Q

CGRP antagonist

A

Galcanezumab

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9
Q

Chronic pain are

A

Inflammatory pain, musculoskeletal pain, headache, neuropathy

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10
Q

Neuropathic pain is due to

A

Somatosensory nerve damage

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11
Q

Most common neuropathy

A

Post herpetic neuralgia, diabetic neuropathy, trigeminal neuralgia

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12
Q

Neuropathic pain has

A

Excessive sensitization of neurons and ectopic signal foci

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13
Q

Ectopic signal foci is caused by

A

Over expression of sodium channels

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14
Q

Against neuropathic pain

A

Anti epileptic and antidepressants drugs are used

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15
Q

For nociceptive pain

A

NSAIDS and paracetamol

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16
Q

Nociceptive system connect to

A

Spinothalamic and spinomedullary tract neurons

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17
Q

Classical or typical antipsychotic drugs

A

Haloperidol and chlorprothixene

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18
Q

Atypical (2.gen) drugs

A

Clozapine,Olanzapine,Quetiapine,Aripiprazole

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19
Q

Non specific antipsychotic drugs

A

Melperone and sulpiride

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20
Q

Psychotic states are

A

Schizophrenia and bipolar disorders

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21
Q

4groups of psychotic symptoms

A

Positive,negative, cognitive and affective

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22
Q

Positive symptoms are

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A

Hallucinations, delusion and catatonia (stupor and excitement)

23
Q

Catatonic excitement

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A

Chaotic, unpredictable, stereotypical psychomotor activity

24
Q

Negative symptoms are

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A

Alogia,anhedonia, emotional indifference and social isolation

25
Cognitive symptoms are
Attention and concentration disorder,working memory deficiency
26
Affective symptoms are
Depression, anxiety and suicidality
27
Division of AP into typical and atypical is based on
EPS historical,butewrong Nowadays based on negative symptoms
28
Drugs that cause disease independent negative symptoms are
Typical antipsychotic drugs
29
4major pathways in dopaminergic system
Mesolimbic,mesocortical,nigrostriatal,tuberohypophseal(tuberoinfundibular)
30
Drugs used against positive symptoms are
D2 receptor antagonist working on mesolimbic tract
31
Typical drugs have
Prolonged D2 receptor blockade or slow off dissociation kinetics
32
Typical drugs can cause
Negative symptoms as well
33
D2 receptor blockade SE
EPS,hyperprolactinemia
34
HT2a receptor blockade SE
Anxiety and insomnia
35
H1receptor blocker SE
Drowsiness, appetite,weight gain
36
M cholinoreceptor blocker SE
Dry mouth, urinary retention,blurry vision, constipation,can also cause negative and cognitive symptoms
37
Alpha 1 adrenoreceptor blocker SE
Orthostatic hypotension, reflector tachycardia, dizziness
38
H1 receptor blocker is used to gove
Sedation
39
Antiemetic
Against vomiting
40
Typical AP indication
Schizophrenia and acute mania
41
Atypical AP indication
Schizophrenia and bipolar disorders
42
Aripiprazole is a
D2 partial agonist and HT2a antagonist
43
Aripiprazole use
Schizophrenia, bipolar disorders and acute mania
44
Clozapine main side effect
Agranulocytosis,convulsion ,severe constipation (it can also cause wet cushion syndrome due to M4 stimulation), sedation (H1 block), orthostatic hypotension due alpha 1 adrenoreceptor block))
45
Clozapine is used only
Resistant schizophrenia treatment
46
Melperone use
Schizophrenia and neurotic stage and confusion in seniors
47
Sulpiride uses
Affect negative and affective symptoms without acting on 5HT 2a receptor ,so use in schizophrenia and depressive disorders
48
Akathisia
Desire to move constantly
49
Dystonia
Uncontrollable, abnormal involuntary movement
50
Parkinsonism
Bradykinesia,tremor, rigidity
51
EPS treatment
Trihexyphenidyl(central M cholino blocker)
52
Metabolic disorders caused by AP
Weight gain, hyperprolactinemia, hypercholesterolemia,risk of diabetes
53
Treatment of NMS
Benzodiazepine(against anxiety and agitation),central D2 receptor agonist -bromocriptine,Danteolene- peripheral muscle relaxant(against muscle rigidity and hyperthermia)

Pharma 3 (4 decks)

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