Anatomy Flashcards
(22 cards)
How long do RBC live for?
120 days
What’s a RBCs source of energy?
glucose
How long do platelets live for?
8-10 days
What makes up platelet dense granules?
ADP, Ca2+
What makes up platelet a granules?
vWF and fibrinogen
vWF receptor?
Gp1b
Fibrinogen receptor
GpIIb/IIIa
WBC differentiation
Neutrophils: ~55% Lymphocytes ~30% Monocytes ~5% Eosinophils ~ 2% Basophils ~0%
What do specific granules in PMN’s contain?
Alkaline phosphatase, collagenase, lysozyme, and lactoferrin
What do azuropihilic granules contain?
Proteinases, acid phosphatase, myeloperoxidase, B-glucuronidase
When do you see hypersegmented polys?
Vitamin B12 or folate deficiency
What are the important neutrophil chemotactic agents?
C5a, IL-8, LTB4, platelet-activating factor
Macrophages are activated by?
g-interferon
What binds macrophages to initiate septic shock?
Lipid A from LPS (gram- bac) binds to CD14 on macrophages
Main function of eosinophils?
Helminthic infections
Reasons for eosinophilia?
Parasite infection Asthma Allergies Neoplasm Chronic adrenal insufficiency
Main function of basophil?
Mediates allergic reactions
What do basophils release when stimulated?
Heparin, histamine
Leukotrienes synthesize and released on demand
What is a main cause of basophilia?
CML (myeloproliferative disorders)
What Rx prevents mast cell degranulation?
Cromolyn sodium (used for asthma prophylaxis)
What factors are release from mast cells?
Histamine, heparin, eosinophil chemotactic factors
What is the T cell co-stimulatory signal necessary for activation?
CD28
