Chronic myeloproliferative disorders

Question 1

Chronic myelogenous leukemia

Answer 1

BCR-ABL fusion, Philadelphia cr t(9:22)
Constitutional symptoms
Splenomegaly
Leukocytosis with marked left shift (myelocytes, metamyelocytes, band forms)

Question 2

Essential thrombocytosis

Answer 2

JAK2 (tyrosine kinase) mutation->STAT activation
Hemorrhagic and thrombotic symptoms
thrombocytosis, and megakaryocytic hyperplasia

Question 3

Polycythemia vera

Answer 3

JAK2 (tyrosine kinase) mutation->STAT activation

Pruitus, erythomelalgia, splenomegaly, thrombotic complications, erythrocytosis and thrombocytosis

Question 4

Primary myelofibrosis

Answer 4

JAK2 (tyrosine kinase) mutation->STAT activation

Severe fatigue, splenomegaly (easy satiety), hepatomegaly, anemia, and bone marrow fibrosis