Physiology Flashcards
(22 cards)
Blood typing refers to what?
Antigen found on the RBC
Who gets RhoGAM?
Pregnant mothers who are Rh-, to prevent development of materal anti-Rh IgG
What factors activate X–>Xa
VIIa, VIIIa (cofactor), and IXa
What factors activate II (thrombin)–>IIa
Xa and Va (cofactor)
Hemophilia A
Deficiency of factor VIII (XR)
Hemophilia B
Deficiency of factor IX (XR)
Hemophilia C
Deficiency of factor XI (AR)
What is the enzyme that reduced vitamin K?
Epoxide reductase (Oxidized Vit K->reduced Vit K)
Activated protein C has what function?
Inactivates cofactors Va and VIIIa
What factor does vWF carry and protect?
VIII
Antithrombin inhibits activated forms of which factors?
II, VII, IX, X, XI, XII.
Mainly II and Xa
Factor V leiden mutation
Produces a factor V that is resistant to inhibition by activated protein C
What Rx indirectly decrease GpIIb/IIIa?
Clopidogrel, prasugrel, ticlopidine
Inhibit the ADP receptor that produces GpIIb/IIIa
What Rx directly decrease GpIIb/IIIa?
Eptifibatide, abciximab, and tirofiban
(Inhibit GpIIb/IIIa directly)
EAT GPIIb/IIIa
What Rx activates vWF to bind GpIb?
Ristocetin
Failure of agglutination with ristocetin occurs in?
vonWillebrand diease and Bernard-Soulier syndrome
Bernard-Soulier syndrome is a deficiency in what?
GPIa receptor
What’s in the endothelial cells that gets released during clotting?
vWF+VIII
Thromboplastin
tPA, PGI2
Whats inside the platelet that gets released during clotting?
vWF
Fibrinogen
Glanzmann thrombasthenia
Deficiency in GpbII/aIII (platelets can’t aggregate
von Willebrand disease
Platelets can’t adhere to the wound area
von Willebrand disease test results
Normal PTT, increased bleeding time
