Angioedema & Anaphylaxis/Anaphylactic reaction Flashcards
(15 cards)
Angioedema
Edema in the Face, tongue , mouth , eyes , larynx
* Laryngeal edema – most dangerous
- Etiology of angioedema
- Herediatry Angioedema – C1 esterase inhibitor deficiency
- Aquired Angioedema = ACE-I
lab Findings of angioedema
:
HIGH bradykinin , + LOW C4 level (only in hereditary)
**c4 levels is sensitive screening to differentiate between (hereditary vs acquired)
Treatment of angioedema
1)ABC ,
2)recombinant C1 esterase
inhibitor, Danazol(in hereditary )
3) stop ACE-I (in acquired
Anaphylaxis/Anaphylactic reaction Etiology
*IgE mediated mast cell and basophil activation
* Several Triggers - Food[ Almond , peanuts ] - Medications [Penicillin ] - Bee stung
Anaphylaxis Clinical findings
Cutaneous [Flushing, angioedema, itchy skin]
Respiratory [ dyspnea, coughing ]
GI [Nausea and vomiting, abdominal pain]
Anaphylaxis Treatment
Epinephrine IM
*0.01 mg/kg
AE: of ACE-I
-hyperkalemia
-AKI
-dry cough (bradykinin accumulation )
next step in allergy to penicillin suspicion ?
skin test -specific IGE antibody
+ test =change drug or penicillin desensitization
most allergic drug
penicillin
least allergic drug
aztreonam(monobactam)
most common
cause of anaphylactic out side the hospital
food allergy
most common
cause of anaphylactic in the hospital
penicillin
venom immunotherapy
-slowly venom administration to desensitize
-indications:
*severe symptoms
2 allergic reaction with no EPI improvement
*severe allergy with positive skin test
perioral contact dermatitis
*local irritant reaction
*due to acidity, ,toothpaste ,lipstick ..
*not allergic reaction not IgE mediated
