Chronic Granulomatous Disease – CGD

Question 1

CGD etiology

Answer 1

Defective Phagocyte NADPH – Defective killing process

Question 2

Clinical
:

Answer 2

1- Swollen Lymph nodes
2 – Recurrent infections with catalase positive organisms [Staph. Aureus ,
pseudomonas ]

**recurrent liver/skin abscess

Question 3

Diagnosis

Answer 3

DHR Flow cytometry Test - Nitroblue tetrazolium test – negative

Question 4

Treatment

Answer 4

• TMP-SMX daily - Granulocyte Transfusion - Curative “HSCT”,BMT

Question 5

AE : of TMP-SMX

Answer 5

-pancytopenia
-aplastic anemia
-folic acid deficiency