differential diagnosis

Question 1

how to differentiate between CVID & XLA

Answer 1

CVID= normal b cell count
XLA =absent B cells

Question 2

recurrent staph aureus ddx:

Answer 2

1. CGD = chronic granulomatous disease
2. Hyper IgE Syndrome

Question 2

recurrent bacterial +neutropenia ddx:

Answer 2

1. Chediak Higashi syndrome
2. LAD = Leukocyte Adhesion defect

Question 3

low T –Cell +recurrent viral

Answer 3

Wiskot Aldrich syndrome

Question 4

Mix B + T cell deficiency

Answer 4

1. SCID = Severe combined immunodeficiency
2. DI GEORGE syndrome

Question 5

Complement
system deficiency

Answer 5

1. C1 deficiency →Hereditary Angioedema
2. C5-C9 defic. →Terminal complement deficiency

Question 6

recurrent bacteria infection (nigeria especially)

Answer 6

→Terminal complement deficiency

Question 7

how to differentiate between hereditary vs acquired angioedema

Answer 7

hereditary angioedema: high bradykinin+low C4

acquired angioedema : high bradykinin+normal C4