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Flashcards in Anti coagulants Deck (36):
1

Heparin MOA

Acts as catalyst for antithrombin III

2

Heparin Indications

Prophylaxis for DVT and PE. Used in surgery and IV placement.

3

Heparin Pharmacokinetics

IV only with an immediate onset of action

4

Heparin Adverse effects

Hemorrhage (treat with protamine sulfate), Heparin induced thrombocytopenia.

5

Enoxaparin

LMW heparin

6

Fondaparinux

Synthetic pentasaccharide of heparin

7

LMW heparin pharmacokinetics

Injected Subcutaneously.

8

LMW heparin indications

Used in pregnancy. Lower incidence of HIT.

9

Lepirudin

Direct thrombin Inhibitor, IV only.

10

Lepirudin Indications

HIT alternative to heparin with Renal excretion (used in liver failure)

11

Argatroban

Direct thrombin inhibitor, IV only.

12

Argatroban Indications

HIT alternative to heparin with liver metabolism (used for renal failure)

13

Dabigatran

Direct thrombin inhibitor. Oral.

14

Rivaroxaban

Oral inhibitor of factor Xa

15

Apixaban

Oral inhibitor of factor Xa

16

Edoxaban

Oral inhibitor of factor Xa

17

Warfarin MOA

Inhibits vitamin K epoxidase to stop the synthesis of coagulation factors II, VII, IX and X.

18

Warfarin Adverse effects

Quickly reduces the levels of protein C so thrombosis can occur within the first few days. Co administer with heparin.

19

Warfarin reversal

Vitamin K or fresh frozen plasma

20

Warfarin contraindications

Pregnancy.

21

Warfarin Drug interactions

Antibiotic absorption, estrogen, aspirin.

22

Thrombolytic agents MOA

Converts plasminogen to plasmin with lyses thrombus from within.

23

Thrombolytic agents indications

MI, PE, DVT

24

Aminocaproic acid

Inhibits plasminogen activation. Used in bleeding disorders and reversal of fibrinolytic therapy.

25

Transexamic acid

Inhibits plasminogen activation. Used in bleeding disorders and reversal of fibrinolytic therapy.

26

Alteplase

Clot selective thrombolytic

27

Reteplase

Clot selective thrombolytic

28

Tenecteplase

Clot selective thrombolytic

29

Aspirin MOA

Irreversibly inhibits COX for the lifetime of the platelet

30

Aspirin indications

Secondary prevention of CV evens with established CV disease.

31

Clopidigrel MOA

Irreversibly blocks the ADP receptor to inhibit platelet aggregation.

32

Ticlopidine MOA

Irreversibly blocks the ADP receptor to inhibit platelet aggregation.

33

DOC for thrombosis prevention in stent placement

Clopidigrel

34

Abciximab

Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.

35

Eptifibatide

Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.

36

Tirofiban

Inhibitor of GPIIb/IIIa receptor. IV only. Decreased platelet aggregation.