Endocrine Drugs Flashcards Preview

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Flashcards in Endocrine Drugs Deck (148):
1

Leupropride

Long acting GnRH agonist

2

Tamoxifen

SERM

3

Endometriosis DOC

Long acting GnRH agonists

4

Mifepristone (RU 486)

Anti-progestin and anti-glucocorticoid

5

Toremifene

SERM

6

Fulvestrant

Full estrogen receptor antagonist

7

Spironolactone

Androgen receptor antagonist and aldosterone antagonist

8

Dutasteride

5 alpha reductase inhibitor

9

Urofollitropin

FSH gonadotropin

10

Clomiphene

SERM

11

Letrozole

Aromatase inhibitor

12

Flutamide

Androgen receptor antagonist

13

Gosereline

Long acting GnRH agonist

14

Cetroelix

GnRH antagonist

15

Finasteride

5 alpha reductase inhibitors

16

Tolbutamide

Sulfonylurea

17

Metformin

DOC for DMII

18

Miglitol

alpha-glucosidase inhibitor

19

Bromocriptine

Dopamine agonist

20

Ganirelix

GnRH antagonist

21

hMG

FSH gonadotropin

22

Reloxifene

SERM

23

Canagliflozin

SGLT2 inhibitor

24

Glipizide

Sulfonylurea

25

Rosiglitazone

Thiasolidinediones

26

Exenatride

incretin mimetic

27

Stiagliptin

DDP IV inhibitors

28

hCG

LH gonadotropin

29

Pre-menopausal breast cancer DOC

Tamoxifen

30

Anastrole

Aromatase inhibitors

31

Danazol

Anti-progestin (week progestin and androgen)

32

Acarbose

alpha- glucosidase inhibitor

33

Lispro (humalog)

Rapid acting insulin

34

Degludec

Long acting insulin

35

Exemastane

Aromatase inhibitor

36

Tolazadmide

Sulfonylurea

37

Pioglitazone

TZD

38

Diazoxide

Non-diuretic thiazide (used in insulinomas). Decreases insulin secretion.

39

Glargine

Long acting insulin

40

Glipizide

Sulfonylurea

41

Nateglinide

Meglitinides

42

Linagliptin

DDP IV inhibitors

43

Ergonovbine maleate

Ergot alkaloids

44

DOC for inducing labor

oxytocin

45

Dinoprostone

Prostaglandin

46

Nifedipine

CCB

47

Indomethacin

NSAID to reduce prostaglandin synthesis

48

NPH

Intermediate acting insulin

49

Regular insulin

short acting

50

Isophane insulin

intermediate acting

51

Chlorpropamide

sulfonylurea

52

Liraglutide

incretin mimetic

53

Pramlintide

amylin analog

54

Empagliflozin

SGLT2 inhibitor

55

Detemir

Long acting insulin

56

Methylergonovine

ergot alkaloid

57

glimiperide

sulfonylurea

58

Repaglinide

Meglitinides

59

Dulaglutide

Incretin mimetic

60

Alogliptin

DDP IV inhibitor

61

Dapagliflozin

SGLT2 inhibitor

62

Colesevelam

bile acid binding resin

63

Glargine

Long acting insulin

64

Magnesium sulfate

uterine relaxant

65

Nitroglycerin

uterine relaxant

66

Levothyroxine

T4

67

Propranolol

beta blocker that blocks peripheral conversion of t4 to t3

68

Denosumab

Antibody against RANKL

69

Aledronate

Bisphosphonate

70

Pamidronate

Bisphosphonate

71

Methimazole

Thioamides

72

Liothyronine

T3

73

Teriparatide

Recombinant PTH

74

Zoledronic acid

Bisphosphonate

75

Hydrocortisone/cortisone

Glucocorticoids with mineral corticoid activity. Replacment therapy.

76

Flucticasone

Anti-inflammator glucocorticoid

77

Ketoconazole

Corticosteroid inhibitor

78

Ibandronate

bisphosphonate

79

Etidronate

bisphosphonate

80

Propylthiouracil (PTU)

Thioamide

81

Risedronate

bisphosphonate

82

Prednisone/prednisolone

Glucocorticoid

83

Triamcinolone

Anti-inflammatory glucocorticoid

84

Dexamethasone

Anti-inflammatory glucocorticoid

85

Fludrocortisone

Aldosterone glucocorticoid

86

Aminoglutethimide

corticosteroid inhibitor

87

DOC for infertility

Clomiphene (clomid) SERM

88

DOC for post menopausal Breast CA

Aromatase inhibitors

89

Prophylaxis of DM

TZDs (Pioglitazine)

90

Insulins Used IV

Rapid (lispro, aspart, glulisine) and short (regular) acting

91

Type II DM drugs that cause weight loss

Incretin mimetics and pramlintide

92

Type II DM drugs that are injected

Incretin Mimetics and pramlintide

93

Type II DM drugs that can cause hypoglycemia

Sulfonylureas and Meglitinides

94

Post partum hemorrhage choices

Massage, Oxytocin, Ergot Alkaloids, Corboprost Tromethamine.

95

DOC for cervical ripening

Dinoprostone

96

Corboprost Tromethamine

Prostaglandin

97

DOC for hypothyroid

Levothyroxine

98

DOC for Graves

Thioamides (methimazole)

99

DOC for post- menopausal osteoporosis

Bisphosphonates

100

Oral Bisphosphonates

Aledronate, Risedronate, Ibandronate, Etidronate

101

IV Bisphosphonates

Ibandronate, Etidronate, Zoledronic Acid, Pamidronate

102

DOC hyproparathyroidism

Teriparatide

103

DOC hypoaldersteronism

Fludrocortisone

104

DOC for Adrenal insufficiency

Hydrocortisone/Cortisone

105

SERM MOA

Antagonist in the breast, agonist in the bone and uterus (except reloxifene)

106

Aromatase Inhibitor MOA

Blocks sythesis of estrogens

107

Mifepristone MOA

Progesterone and glucocorticoid receptor antagonist

108

5 alpha reductase MOA

Inhibits the synthesis of DHT

109

Sulfonylureas MOA

Block K channels to stimulate insulin release

110

Meglitinide MOA

Similar to sulfonylureas (but not sulfa drugs)

111

Thiazolidinediones MOA

Ligand for PPAR-gamma receptor to increase insulin sensitivity

112

Alpha-glucosidease inhibitor

Reduces carbohydrate digestion and absorption

113

Incretin Mimetic MOA

Increase insulin release and slows gastric emptying

114

Pramlintide MOA

Analog of amylin. Supresses post prandial glucagon release. Used as an adjunct to insulin therapy.

115

SGLT2 inhibitors MOA

Glucose is peed out

116

Ergot Alkaloid MOA

Strong contraction of uterine muscle via serotonin and alpha-adrenergic receptors

117

Thioamides MOA

Decreases synthesis and release of T4. Blocks peripheral conversion.

118

Propranolol MOA

Beta blocker that also blocks peripheral conversion of T4 to T3

119

Teriparatide MOA

Recombinant PTH. Produces bone growth.

120

Calcitonin MOA

Antagonizes PTH

121

Denosumab MOA

antibody to the RANKL inhibits osteoclast activity.

122

Bisphosphonate MOA

PCP analog that is incorporated into the bone

123

Diarrhea Drugs

Metformin, quinidine, dinoprostone, erythromycin, colchicine

124

Gonadotropin side effects

Ovarian hyperstimulation

125

SERM used for osteoporosis

Reloxifene

126

Androgen uses

Testicular deficiency, hypopituitarism (Women), Nephrosis and Negative N balance.

127

Flutamid Uses

Prostate cancer along with a long-acting GnRH agonist

128

5 alpha reductase uses

BPH and baldness

129

Type II DM drugs that can cause hypoglycemia

sulfonylureas, meglitinides, insulin

130

Prophylactic DM II drugs

TZDs (pioglitazone)

131

Metformin side effects

Lactic Acidosis and Diarrhea

132

Metformin Contraindications

Lactic acid conditions: renal/hepatic disease, hypoxia (CHF, COPD)

133

TZD side effects

Weight gain, edema

134

TZD contraindications

hepatic disease and CHF. Rosiglitazone has black box warning for increased risk of MI/stroke

135

Incretin mimetic side effects

Pancreatitis

136

DDP IV inhibitor side effects

Pancreatitis

137

alpha glucosidase inhibitors

Flatulence

138

The Sulfonylureas

tolbutamide, chlorpropamide, tolazadmide, glyburide, glipezide, glimiperide

139

The meglitinides

Repaglinide, nateglinide

140

The alpha glucosidase inhibitors

Acarbose, miglitol

141

The incretin mimetics

Exenatride, liraglutide, dulaglutide

142

The aromatase inhibitors

Anastrol, letrozole, exemastane.

143

Oxytocin side effects

Water intoxication, uterine rupture, bradycardia of the fetus

144

Dinoprostone side effects

Diarrhea

145

Indomethacin side effects

Partial closure of the ductus arteriosus

146

PTU side effects

Acute liver failure. Only used if allergic to methimazole or pregnant

147

The Thioamides

PTU and methimazole

148

The corticosteroid inhibitors

aminoglutethimide and ketoconazole