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CPT Drugs > Anti-epileptic drugs? > Flashcards

Anti-epileptic drugs? Flashcards

1
Q

Benzodiazepines

A

Diazepam, Lorazepam, Midazalam

Potentate GABA activity at GABAa receptors

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2
Q

Na channel blockers

A

Carbamazepine, Phenytoin, Lamotrigine

Carbamazepine - trigeminal neuralgia too

Blocks Na channels so slows recovery of inactive neurones
Reduced Ca influx - reduced transmission

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3
Q

Na channel blockers DDIs, ADRs, Contraindications

A

Teratogenic

Bone marrow suppression
Hyponatraemia

CYP3A4 inducer - reduces COCP + warfarin effect
CYP3A4 inhibitor - carbamazepine (autoinduction of it’s own metabolism so need to ^dose over time)

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4
Q

Sodium Valproate - main ADR?

A

Na blocker

Teratogenic

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5
Q

Levetiracetam

A

SAFE IN PREGNANCY

Synaptic vesicle 2A Inhibition
Prevents Ca influx - neurotransmitter doesn’t get released

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6
Q

How long do you wait during a seizure before giving meds?

A

5 mins

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7
Q

Treatment steps for seizure?

A
  1. Lorazepam i.v. (benzodiazepine)
  2. Lorazepam i.v. (benzodiazepine)
  3. Phenytoin / Sodium Valproate
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CPT Drugs (19 decks)

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