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CPT Drugs > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

What’s the fractional cell kill hypothesis?

A

A given dose of chemo kills a constant proportion of tumour cells rather than a constant number

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2
Q

Alkylating Agents

A

Cisplatin, Oxaliplatin

Stops DNA replication

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3
Q

Antimetabolites

A

Methotrexate - dihydrofolate reductase inhibitor

5-Fluorouracil - Inhibits thymidilate synthase

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4
Q

Spindle poisons

A

Vincristine, Paclitaxel

Can’t undergo mitosis so apoptosis happens

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5
Q

ADRs of chemo?

A

N+V - direct effect on CTZ

Alopecia - scalp cooling can help

Skin toxicity - beau’s lines (fingernails), extravasation (drug leaks from veins to surrounding tissues)

Mucositis

Neutropenia

Renal toxicity

Cardio toxicity

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6
Q

Cisplatin and Carboplatin ADR?

A

Ototoxicity
Nephrotoxicity

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7
Q

Vincristine ADR?

A

Peripheral neuropathy

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8
Q

Bleomycin ADR?

A

Pulmonary fibrosis

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9
Q

Cyclophosphamide ADR?

A

Haemorrhagic cystitis (mesna/hydration helps)

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CPT Drugs (19 decks)

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