GI Pharmacology

Question 1

PPI

Answer 1

Omeprazole, Lansoprazole

Peptic Ulcer disease

Irreversibly inhibits H/K ATPase in parietal cells

Question 2

PPI issues?

Answer 2

Abdo pain, Constipation/diarrhoea

Masks symptoms of gastro-oesophageal cancer

Omeprazole is a CYP inhibitor -
reduces clopidogrel activation
Increased effects of warfarin / phenytoin

Question 3

H2 Receptor antagonists

Answer 3

Ranitidine

Inhibits H2 at parietal cells - reduced histamine

CURRENT LARGE SCALE RECALL ON RANITIDINE PRODUCTS

Question 4

Gaviscon

Answer 4

Alginic acid + antacid

Buffers stomach acid

Magnesium Carbonate - Diarrhoea
Aluminium hydroxide - Constipation

Question 5

Aminosalicylates

Answer 5

Mesalazine

Ulcerative colitis - 1st line treatment

Releases 5-aminosalicylic acid (anti-inflammatory)

Enteric coated - topical action at colon

Question 6

H Pylori treatment

Answer 6

Lansoprazole + clarithromycin + Amoxicillin/metronidazole

(+ve urea breathe test)