anti-fungals and assorted mx Flashcards
(26 cards)
amphotericin MOA?
binds ergosterol and forms pores
amphotericin uses?
systemic mycoses
e.g. crypto, blasto, coccidioides, histoplasma, candida, mucor
**supplement K and Mg - altered renal tubule permeability
amphotericin toxicity?
shake and bake hypoT nephrotoxicity (dose-dependent, reversible) anemia IV phlebitis
nystatin MOA?
same as amphotericin
too toxic for systemic - topical only
nystatin uses?
swish and swallow
diaper rash, vaginal candidiasis
flucytosine MOA?
inhib DNA/RNA synth: cytosine deaminase converts to 5FU
flucytosine uses?
with ampho!
for crypto meningitis (or other systemic fungal infx)
flucytosine toxicity?
bone marrow suppression
azole MOA?
inhibit ergosterol synth by inhibition of CYP450 enzyme
azole uses?
fluconazole: chronic crypto meningitis suppression in AIDS, all candidal infx
itraconazole: blasto, coccidio, histo
clotrimazole, miconazole: topical
azole toxicity?
testosterone synthesis inhibition
liver dysfn
terbinafine MOA?
inhibits squalene epoxidase
terbinafine uses?
onychomycosis, other dermatophytoses
terbinafine toxicity?
GI
H/A
hepatotoxicity
taste disturbance
echinocandin MOA?
inhibit beta-glucan synthesis
echinocandin uses?
invasive aspergillosis
candida
echinocandin toxicity?
GI
flushing
griseofulvin MOA?
interferes with microtubule formation - disrupts mitosis
deposits in keratin-containing tissues
griseofulvin uses?
dermatophytes
griseofulvin toxicity?
teratogen carcinogen confusion H/A upregulates CYP450 and warfarin metabolism
permethrin MOA?
blocks Na channels –> neurotoxicity
malathion MOA?
ACh-esterase inhib
lindane MOA?
blocks GABA channels –> neurotoxicity
chloroquine MOA?
blocks heme –> hemozoin
heme accumulation = toxic to plasmodia
