Anti-inflammatory_arthritis_gout Flashcards
(48 cards)
Name two salicylates examples
Aspirin
81mg-baby asprin
325mg-fever reducer
-EC, PO, Chewable
Aspirin-acetaminophen-caffeine (Excedrin)-(migraine)
Bismuth subsalicylate (Pepto-Bismol)-upset stomach, diarrhea
What is chewable salicylate aspirin used for?
Chewable aspirin is given for MI, and has a faster effect than swallowing.
Salicylates MOA
inhibit synthesis of prostaglandin.
Salicylates indication is?
treat mild to moderate pain/ fever
MI’s and prevention by inhibition of platelet aggregation
What other reasons may salicylates be used for?
Salicylates can be given for MI prevention, stroke prevention
What are the side effects of salicylates
Nausea, dyspepsia (indegestion),
-clotting systems (prolonged bleeding time),
-Reye’s syndrome in children*
What are the adverse effects of aspirin due to asprin toxicity?
Salicylism- (dizziness, mental confusion, tinnitus*, sweating, hyperventilation/respiratory alkalosis.
What do salicylates interreact with?
NSAIDS
Blood thinners (Warfarin)
What can contraindicate salicylates?
bleeding abnormalities (ASA prolongs bleeding/interacts with blood thinners)
impaired renal function
What would you educate a patient about salicylates
·Patient ed:
· Stop one week before surgery
· Monitor for bruising, bleeding gums, coffee-ground emesis, Dark tarry stool
· -Do NOT give to children and teens with recent viral infection or fever- (Reyes syndrome)
· Can take with food, milk or antacid to avoid GI irritation.
NSAIDs examples
- Ibuprofen
- Naproxen
- Diclofenac
- Ketorolac
- Indomethacin (PO, R, or IV)
- nabumetone (Relafen)
- meloxicam (Mobic)
- Cyclooxygenase-2 Inhibitors (Celecoxib)
NSAIDs MOA
non-selective inhibition of cyclooxygenase
enzyme that controls pain, fever, inflammation
as well as thromboxane which stimulated the clotting of blood.
Ibuprofen indication
inflammation and pain, dysmenorrhea, musculoskeletal disorders
Naproxen indications
Joint and arthritis pain
Indomethacin indication
- acute gout,
- tendonitis, pericarditis
- neonates to promote closure of the duct between the pulmonary artery and aorta
Ketorolac Indications
*short term use (5 days), mod-severe pain & inflammation-post-op
Nabumetone indication
(Relafen)- mild-mod OA, RA and gouty arthritis
*Celecoxib indication
- Celecoxib- OA, RA, pain
NSAIDS side effects and adverse effects
Nausea & vomiting (most common),*
dyspepsia (mucosal lesion-ulcer),* burring!
GI bleed, (impacts GI a lot)* GI pain*
acute renal failure*
platelet inhibition, blood clotting issues*
-report allll the above
What should you be aware of for patients on NSAIDs about their condition?
Ask for any stomach or kidney disorders (cuz of peptic ulcer, GI pain/bleeding,
NSAIDS are hard on the stomach and kidneys (renal failure)
NSAIDS interactions
Anticoagulants
Corticosteroids
diuretics,
decrease
the antihypertensive effect of beta-blockers
(Heart meds) (aspirin)
NSAIDs contraindications
Peptic Uclers (indesgestion),*
GI bleeding*
Pregnancy D,*
bleeding disorders,*
Renal and hepatic dysfunction,*
Vit K deficiency,*
(Stomach or kidney problems)
What are all the nursing implications for NSAIDS
· NSAIDs can compromise existing renal function
· Renal toxicity can occur in patients with dehydration, heart failure, liver dysfunction, or use of diuretics or ACE inhibitors.
· Assess: CBC (to monitor for blood loss/ blood clotting ability), liver and renal function, GI disorders - bleeding or peptic ulcer
which drug decreases inflammation, fever, and pain but does not decrease platelet aggregation
COX-2
