Anti-microbials

Question 1

Everything about Aminoglycosides

Answer 1

Inhibit 50s ribosome unit BUT it’s BACTERIOCIDAL!
Neomycin is for gut cleaning
Paromycin is for parasites
Streptomycin is for Francisella, Yersinia, and others
Pseudomonas is treated with Gentamicin
Toxicities: NNOT (nephrotoxicity, neuromuscular blockade, ototoxicity, teratogenicity)

Question 2

Which antifungal is a nucleic acid synthesis inhibitor and what is the MOA, clinical use, and adverse effects?

Answer 2

Flucytosine - Converted by cytosine deaminase to 5-fluorouracil. leads to miscoding
Systemic fungal infections (meningitis caused by cryptococcus) in combo with ampho B
Bone marrow suppression

Question 3

Everything about Tetracyclines

Answer 3

can treat MRSA infections
bacteriostatic 30s ribosome inhibitor
tx for Coxiella, Brucella, Yersinia, Mycoplasma pneumonia, Chlamydia
adverse effects: tooth discoloration in kids, photosensitivity, GI problems (N/V/D)
teratogen for fetus
Fanconi syndrome (type 2 RTA) if use of expired tetracyclines
Efflux pumps are how bacteria resist tetracyclines