Heme/Onc Flashcards
1
Q
What receptor does VWF bind to at site on injury during adhesion?
Features of Von Willebrand disease. Inheritance?
A
GpIb - then platelets undergo change and release ADP, Ca, and TXA2
Impaired aggregation so normal platelets.
VWF carries and protects VII so PTT is prolonged but PT is normal.
Aut. DOM. so family history is key (mother who died during childbirth, etc)
2
Q
What is the treatment time for Von Willebrand disease and why?
A
Desmopressin - promotes release of vWF and VIII (good for hemophilia A too) from endothelial cells
3
Q
What two things degrade bradykinin?
A
ACE and C1 inhibitor protein
Block these?
Angioedema, cough, etc.
