Anti-Phospholipid Syndrome Flashcards Preview

MS/Rheum > Anti-Phospholipid Syndrome > Flashcards

Flashcards in Anti-Phospholipid Syndrome Deck (9)
Loading flashcards...
1
Q

What are two conditions you’d expect with APS?

A

thrombosis (arterial or venous)

recurrent miscarriages

2
Q

Auto Abs

A

IgA anti-B2-glycoprotien 1 (more common)

IgA anti-cardiolipin Ab

3
Q

Epidemiology?

A

prevalence increases with age

4
Q

Most common venous manifestation? Arterial?

A

DVT

Stroke

5
Q

Pregnancy losses typically occur after:

How can you prevent this?

A

10 wks genstation

low dose aspirin and heparin

6
Q

What is Catastrophic APS?

A

rare form of APS that consists of multiple thromboses of medium and small arteries occurring over days

7
Q

What lab values will be positive?

A

aPLs
Microhematuria
non-nephrotic proteinuria
Coombs test

8
Q

Clinical features?

A

o Livedo reticularis
o Thrombocytopenia
o Autoimmune hemolytic anemia
o Vegetations or thickening on cardiac valves
o Renal impairment due to ischemia in the small renal vessels
o MS like symptoms

9
Q

Pathogenesis:

A
  1. apoptosis&raquo_space; inefficiently cleared cells
  2. AutoAbs against B2-glycoprotein 1 develop + loss of tolerance (APC > T > B > Ab)
  3. Ab bind membranes of endothelial cells, platelets, monocytes, and trophoblasts
  4. complement activated&raquo_space; symptoms