Flashcards in SLE Deck (21):
Most common subtype
Discoid Lupus Erythematous (confined to skin)
When does drug-induced lupus resolved?
when drug d/c
Symptoms of Neonatal SLE?
-skin rash (transient)
-heart block (permanent)
*newborns of SLE mothers
Symptoms of subacute cutaneous SLE?
nonscarring papulosquamous lesions resembling psoriasis or annular-polycyclic lesions with peripheral scale and central clearing
Etiology of subacute cutaneous SLE?
1. Induced by drugs: ACEI's, hydrochlorothiazide, terbinafine and CCB's
2. Can develop as para-neoplastic syndrome
May progress to squamous cell carcinoma
Chronic Cutaneous LE
photosensitive lesions that can lead to skin atrophy and scar
Chronic Cutaneous LE
Epidemiology of SLE?
AA > white
F > males
Peak incidence in childbearing years
More severe at younger ages
complement C4A deficiency
Environmental factors in pathogenesis
What induces cellular apoptosis?
These dying cells release:
genetic predisposition + UV
HMGB1 and Beta defensins (bind and activate TLRs of innate immune system cells)
What activates plasmacytoid DC?
What is the function of these cells?
INF-1, produced by macrophages
Plasmacytoid DC cells take up + present DNA and histones (inefficiently removed apoptosed cells) in lymphoid tissues
What causes the breakdown of normal tolerance?
DC >> Self-Ag presented to T cells >> stimulate B cells to make autoAbs
What causes inflammation?
complement activation >> neutrophils
RASH PAIN O MD:
Renal, arthritis, serositis, hematologic, photosensitivity, ANA +, Immunologic, Neuorologic, Oral Ulcer, Malar Rash, Discoid Rash
How is SLE-associated arthritis characterized?
Symmetrical, NON-erosive, deforming, myositis and weakness
How is SLE-associated serositis characterized?
pleuritis, pericarditis, inflammation of peritoneal cavity (abd pain)
What are possible SLE-associated heme abn?
hemolytic anemia, leukopenia, lymphopenia, thrombocytopenia
What are SLE-associated neurologic symptoms?
Depression, psychosis, seizures, MS-like dz, periph neuropathy
SLE-associated skin symptoms?
Alopecia (telogen effluvium or alopecia areata)