SLE Flashcards
(21 cards)
Most common subtype
Discoid Lupus Erythematous (confined to skin)
When does drug-induced lupus resolved?
when drug d/c
Symptoms of Neonatal SLE?
- skin rash (transient)
- heart block (permanent)
*newborns of SLE mothers
Symptoms of subacute cutaneous SLE?
nonscarring papulosquamous lesions resembling psoriasis or annular-polycyclic lesions with peripheral scale and central clearing
Etiology of subacute cutaneous SLE?
- Induced by drugs: ACEI’s, hydrochlorothiazide, terbinafine and CCB’s
- Can develop as para-neoplastic syndrome
May progress to squamous cell carcinoma
Chronic Cutaneous LE
photosensitive lesions that can lead to skin atrophy and scar
Chronic Cutaneous LE
Epidemiology of SLE?
AA > white
F > males
Peak incidence in childbearing years
More severe at younger ages
Susceptibility genes
HLA-D2
HLA-DR-3
complement C4A deficiency
Environmental factors in pathogenesis
UV light
Pathogenesis:
What induces cellular apoptosis?
These dying cells release:
genetic predisposition + UV
HMGB1 and Beta defensins (bind and activate TLRs of innate immune system cells)
Pathogenesis:
What activates plasmacytoid DC?
What is the function of these cells?
INF-1, produced by macrophages
**central player
Plasmacytoid DC cells take up + present DNA and histones (inefficiently removed apoptosed cells) in lymphoid tissues
Pathogenesis:
What causes the breakdown of normal tolerance?
DC»_space; Self-Ag presented to T cells»_space; stimulate B cells to make autoAbs
Pathogenesis:
What causes inflammation?
complement activation»_space; neutrophils
Clinical presentation?
RASH PAIN O MD:
Renal, arthritis, serositis, hematologic, photosensitivity, ANA +, Immunologic, Neuorologic, Oral Ulcer, Malar Rash, Discoid Rash
How is SLE-associated arthritis characterized?
Symmetrical, NON-erosive, deforming, myositis and weakness
How is SLE-associated serositis characterized?
pleuritis, pericarditis, inflammation of peritoneal cavity (abd pain)
What are possible SLE-associated heme abn?
hemolytic anemia, leukopenia, lymphopenia, thrombocytopenia
What are SLE-associated neurologic symptoms?
Depression, psychosis, seizures, MS-like dz, periph neuropathy
SLE-associated skin symptoms?
Knuckles spared
Discoid rash
Alopecia (telogen effluvium or alopecia areata)
Auto Abs
o Anti-dsDNA o Anti-smith o Anti-U1RNP o Anti-Ro/SSA, La/SSB o Anti-histone o Anti-phospholipid
Lauren SHURDs her Pants
Lupus = smith, histone, U1, Ro, dsDNA, phos
