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Flashcards in SLE Deck (21):
1

Most common subtype

Discoid Lupus Erythematous (confined to skin)

2

When does drug-induced lupus resolved?

when drug d/c

3

Symptoms of Neonatal SLE?

-skin rash (transient)
-heart block (permanent)

*newborns of SLE mothers

4

Symptoms of subacute cutaneous SLE?

nonscarring papulosquamous lesions resembling psoriasis or annular-polycyclic lesions with peripheral scale and central clearing

5

Etiology of subacute cutaneous SLE?

1. Induced by drugs: ACEI's, hydrochlorothiazide, terbinafine and CCB's
2. Can develop as para-neoplastic syndrome

6

May progress to squamous cell carcinoma

Chronic Cutaneous LE

7

photosensitive lesions that can lead to skin atrophy and scar

Chronic Cutaneous LE

8

Epidemiology of SLE?

AA > white
F > males
Peak incidence in childbearing years
More severe at younger ages

9

Susceptibility genes

HLA-D2
HLA-DR-3
complement C4A deficiency

10

Environmental factors in pathogenesis

UV light

11

Pathogenesis:
What induces cellular apoptosis?
These dying cells release:

genetic predisposition + UV

HMGB1 and Beta defensins (bind and activate TLRs of innate immune system cells)

12

Pathogenesis:
What activates plasmacytoid DC?
What is the function of these cells?

INF-1, produced by macrophages
**central player

Plasmacytoid DC cells take up + present DNA and histones (inefficiently removed apoptosed cells) in lymphoid tissues

13

Pathogenesis:
What causes the breakdown of normal tolerance?

DC >> Self-Ag presented to T cells >> stimulate B cells to make autoAbs

14

Pathogenesis:
What causes inflammation?

complement activation >> neutrophils

15

Clinical presentation?

RASH PAIN O MD:

Renal, arthritis, serositis, hematologic, photosensitivity, ANA +, Immunologic, Neuorologic, Oral Ulcer, Malar Rash, Discoid Rash

16

How is SLE-associated arthritis characterized?

Symmetrical, NON-erosive, deforming, myositis and weakness

17

How is SLE-associated serositis characterized?

pleuritis, pericarditis, inflammation of peritoneal cavity (abd pain)

18

What are possible SLE-associated heme abn?

hemolytic anemia, leukopenia, lymphopenia, thrombocytopenia

19

What are SLE-associated neurologic symptoms?

Depression, psychosis, seizures, MS-like dz, periph neuropathy

20

SLE-associated skin symptoms?

Knuckles spared
Discoid rash
Alopecia (telogen effluvium or alopecia areata)

21

Auto Abs

o Anti-dsDNA
o Anti-smith
o Anti-U1RNP
o Anti-Ro/SSA, La/SSB
o Anti-histone
o Anti-phospholipid

Lauren SHURDs her Pants
Lupus = smith, histone, U1, Ro, dsDNA, phos