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Flashcards in SLE Deck (21)
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1
Q

Most common subtype

A

Discoid Lupus Erythematous (confined to skin)

2
Q

When does drug-induced lupus resolved?

A

when drug d/c

3
Q

Symptoms of Neonatal SLE?

A
  • skin rash (transient)
  • heart block (permanent)

*newborns of SLE mothers

4
Q

Symptoms of subacute cutaneous SLE?

A

nonscarring papulosquamous lesions resembling psoriasis or annular-polycyclic lesions with peripheral scale and central clearing

5
Q

Etiology of subacute cutaneous SLE?

A
  1. Induced by drugs: ACEI’s, hydrochlorothiazide, terbinafine and CCB’s
  2. Can develop as para-neoplastic syndrome
6
Q

May progress to squamous cell carcinoma

A

Chronic Cutaneous LE

7
Q

photosensitive lesions that can lead to skin atrophy and scar

A

Chronic Cutaneous LE

8
Q

Epidemiology of SLE?

A

AA > white
F > males
Peak incidence in childbearing years
More severe at younger ages

9
Q

Susceptibility genes

A

HLA-D2
HLA-DR-3
complement C4A deficiency

10
Q

Environmental factors in pathogenesis

A

UV light

11
Q

Pathogenesis:
What induces cellular apoptosis?
These dying cells release:

A

genetic predisposition + UV

HMGB1 and Beta defensins (bind and activate TLRs of innate immune system cells)

12
Q

Pathogenesis:
What activates plasmacytoid DC?
What is the function of these cells?

A

INF-1, produced by macrophages
**central player

Plasmacytoid DC cells take up + present DNA and histones (inefficiently removed apoptosed cells) in lymphoid tissues

13
Q

Pathogenesis:

What causes the breakdown of normal tolerance?

A

DC&raquo_space; Self-Ag presented to T cells&raquo_space; stimulate B cells to make autoAbs

14
Q

Pathogenesis:

What causes inflammation?

A

complement activation&raquo_space; neutrophils

15
Q

Clinical presentation?

A

RASH PAIN O MD:

Renal, arthritis, serositis, hematologic, photosensitivity, ANA +, Immunologic, Neuorologic, Oral Ulcer, Malar Rash, Discoid Rash

16
Q

How is SLE-associated arthritis characterized?

A

Symmetrical, NON-erosive, deforming, myositis and weakness

17
Q

How is SLE-associated serositis characterized?

A

pleuritis, pericarditis, inflammation of peritoneal cavity (abd pain)

18
Q

What are possible SLE-associated heme abn?

A

hemolytic anemia, leukopenia, lymphopenia, thrombocytopenia

19
Q

What are SLE-associated neurologic symptoms?

A

Depression, psychosis, seizures, MS-like dz, periph neuropathy

20
Q

SLE-associated skin symptoms?

A

Knuckles spared
Discoid rash
Alopecia (telogen effluvium or alopecia areata)

21
Q

Auto Abs

A
o Anti-dsDNA
o Anti-smith
o Anti-U1RNP
o Anti-Ro/SSA, La/SSB
o Anti-histone
o Anti-phospholipid

Lauren SHURDs her Pants
Lupus = smith, histone, U1, Ro, dsDNA, phos