Antibiotics

Question 1

What are the two divisions of antibiotics that work on DNA replication?

Answer 1

Fluoroquinolones and Metronidazole

Question 2

Name two broad spectrum fluoroquinolones

Answer 2

Levofloxacin and Ciprofloxacin

Question 3

What is the mechanism of antibiotics that prevent RNA synthesis?

Answer 3

RNA polymerase inhibitor

Question 4

Name some RNA polymerase inhibitor drugs?

Answer 4

Rifampicin
Fidaxomicin
Anti-TB drugs

Question 5

What three classes of antibiotics prevent protein synthesis?

Answer 5

Macrolides
Aminoglycosides
Tetracyclines

Question 6

Name a macrolide antibiotic?

Answer 6

Clarithromycin

Question 7

Name an aminoglycoside antibiotic

Answer 7

Gentamicin

Question 8

Name a tetracycline antibiotic

Answer 8

Doxycycline

Question 9

What classes of antibiotics work against cell wall synthesis?

Answer 9

Vancomycin

B-Lactams

Question 10

What are the three types of B-lactam antibiotics?

Answer 10

Penicillins
Cephalosporin
Carbapenem

Question 11

What are the three classes of penicillins?

Answer 11

Broad
B-lactamase resistant
Extended spectrum

Question 12

Name some broad spectrum penicillins

Answer 12

Amoxicillin

Question 13

Name a B-lactamase resistant penicillin

Answer 13

Flucloxacillin

Question 14

Name an extended spectrum penicillin

Answer 14

Piperacillin

Question 15

Name two 3rd generation cephaloporins

Answer 15

Cefotaxime

Ceftazidime

Question 16

Name two carbapenem

Answer 16

Meropenem

Imipenem

Question 17

Name an antibiotic that prevents folate synthesis

Answer 17

Trimethoprim
Sulphonamide
(Co-trimoxazole)

Question 18

What is the treatment for pneumococcal pneumonia?

Answer 18

Amoxicillin
Benzyl penicillin
Cephalosporin

Question 19

What is the treatment for staphylococcal pneumonia?

Answer 19

Flucloxacillin

Rifampicin

Question 20

What is the treatment for klebsiella pneumonia?

Answer 20

Cefotaxime or imipenem

Question 21

What is the treatment for pseudomonas pneumonia

Answer 21

Anti-pseudomonal penicillin, ceftazidime, meropenem or ciprofloxacin and aminoglycoside

Question 22

What is the treatment for mycoplasma pneumonia?

Answer 22

Clarithromycin or doxycycline or a fluoroquinolone

Question 23

What is the treatment for legionella pneumonia?

Answer 23

Fluoroquinolone or clarithromycin

Question 24

What is the treatment for chlamydophilia psittaci?

Answer 24

Doxycycline or clarithromycin

Question 25

What is the treatment for pneumocystis pneumonia?

Answer 25

High dose co-trimoxazole or pentamidine IV

Question 26

What is the treatment for severe proven spontaneous bacterial peritonitis?

Answer 26

Piperacillin/Tazobactam Then Co-trimoxazole

Question 27

What is the treatment for mild proven spontaneous bacterial peritonitis?

Answer 27

Co-trimoxazole

Question 28

What is the treatment for non-severe C. diff?

Answer 28

Metronidazole

Question 29

What is the treatment for severe C. diff?

Answer 29

Vancomycin +/- Metronidazole

Question 30

What is the treatment for recurrent C. diff?

Answer 30

Fidaxomicin

Question 31

What is the treatment for Native valve indolent (subacute) endocarditis?

Answer 31

Amoxicilllin Gentamicin

Question 32

What is the treatment for Native valve severe sepsis (acute) endocarditis?

Answer 32

Flucloxacillin

Question 33

What is the treatment for Prosthetic valve MRSA endocarditis?

Answer 33

Vancomycin Rifampicin Gentamicin

Question 34

What is the treatment for Native valve severe sepsis and risk factors of specific resistance endocarditis?

Answer 34

Vancomycin Meropenem

Question 35

What is the treatment for enterococcus endocarditis?

Answer 35

Amoxicillin Vancomycin Gentamicin

Question 36

What is the treatment for Viridans endocarditis?

Answer 36

Penicillin Gentamicin

Question 37

What is the treatment for IV drug user endocarditis?

Answer 37

Flucloxacillin

Question 38

What is the treatment for Epidermidis endocarditis?

Answer 38

Vancomycin Gentamicin

Question 39

What is the treatment for peritonitis/biliary/intra-abdominal?

Answer 39

IV Amoxicillin Metronidazole Gentamicin Then PO Co-trimoxazole Metronidazole

Question 40

What is the 1st line treatment for an acute exacerbation of COPD?

Answer 40

Amoxicillin 500mg tds

Question 41

What is the 2nd line treatment for an acute exacerbation of COPD?

Answer 41

Doxycycline 200mg day one then 100mg (5 days)

Question 42

What is the 1st line treatment for acute cough/bronchitis?

Answer 42

Amoxicillin 500mg tds

Question 43

What is the 2nd line treatment for acute cough/bronchitis?

Answer 43

Doxycycline 200mg day one then 100mg after

Question 44

What is the treatment for mild/moderate CAP?

Answer 44

Amoxicillin (IV/PO 5 Days) | If penicillin allergic Doxycycline

Question 45

What is the treatment for severe CAP?

Answer 45

Co-amoxiclav IV + Doxycycline PO | *If penicillin allergic Levofloxacin

Question 46

What is the treatment for ICU/HDU CAP?

Answer 46

Co-amoxiclav IV + Clarithromycin IV Then Doxycycline *If penicillin allergic Levofloxacin

Question 47

What is the treatment for severe HAP?

Answer 47

IV Amoxicillin+ Metronidazole + Gentamicin Step down to PO Co-trimoxazole + Metronidazole *If penicillin allergic IV Co-trimoxazole + Metronidazole +/- Gentamicin

Question 48

What is the treatment for non-severe HAP?

Answer 48

PO Amoxicillin + Metronidazole | *If penicillin allergic PO Co-trimoxazole + Metronidazole