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Flashcards in Arrhythmia Deck (17):
1

Outline the Vaughn Williams Classifications

IA- Voltage-activated Na channel
IB Voltage-activated Na channel
IC Voltage-activated Na channel
II B-adrenorector (antagonists)
III Voltage-activated K channel
IV Voltage-activated Ca channel

2

Give an example of each class of drug

Ia- disopyramide
Ib- lignocaine
Ic- flecainide
II- metoprolol
III- amiodarone
IV- verapamil

3

What pneumonic can be used to remember the drug names?

Drinking
Lots
oF
Mango
Arrhythmias
Vanish

4

How can you remember the target of vaughn williams classification?

I- Na has 3, SOextra
II- lol
III- three lines in k

5

When do class I anti-arrhythmics bind?

Class I block open state (conducting) and stabilise inactive state, they dissociate in the resting state, therefore if no tachyarrhythmias less binding.

6

Which anti-arrhythmics would you use for rate control of SVT?

Classes IC, III

7

Which anti-arrhythmics would you use for rhythm control of SVT?

Adenosine, digoxin, classes II, IV

8

Which classes would you use for ventricular arrhythmias?

Classes IA, IB, II

9

Which classes would you use for arrhythmias of the atria and ventricles and AV accessory node pathways?

Amiodarone
Sotalol
classes IA, IC

10

Describe the action of adenosine in SVTs

opens GIRK channels in AV node
suppresses conduction

11

Describe the action of digoxin in SVTs

-slows conduction and prolongs refractory period in AV node and bundle of His
used to treat AF

12

Describe the action of verapamil in SVTs

-slows conduction and prolongs refractory period
AF and AF
may cause heart block

13

Describe the use of lignocaine in VTs

Post MI

14

Describe the action of disopyramide in SVTs and in VTs

>block open channels- use dependant
>disopyramide- orally recurrent ventricular arrhythmias
>procainamide- IV to treat ventricular arrhythmias post MI

15

Describe the action of flecainide in SVTs and in VTs

paroxysmal AF
negative inotropic action and may tricker ventricular arrhythmias

16

Describe the action of propranolol in SVTs and in VTs

control SVT and suppress VT

17

Describe the action of amiodarone and sotalol in SVTs and in VTs

suppress reentry
complications of amiodarone