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Flashcards in CLASP Deck (32):
1

What is the target of Herceptin?

Epidermal growth factor receptor

2

Abnormalities in mismatch repair proteins as seen in Lynch Syndrome can be identified by?

Presence of micro satellite instability

3

Which of the following is not a common late side effect of radiotherapy;

Indigestion
Bladder instability
Skin fibrosis Incorrect
Faecal urgency
Menopause

Indigestion

4

What is a risk for oesophageal squamous cell carcinoma?

Plummer Vinson syndrome

5

Malignant cells classically have?

A high nuclear to cytoplasmic ratio

6

Precision/ personalized medicine as it relates to cancer involves

Treatment targeted at specific genetic abnormalities in individual tumours

7

In relation to prostate cancer, prostate-specific antigen (PSA) is widely used for what?

Diagnosis and Monitoring

8

What is human chorionic gonadotrophin and alpha feto protein used to monitor?

Tumour markers for germ cell tumours

9

Small cell carcinoma may result in the excess production of?

ADH

10

A mutation in a promoter will cause?

Absence of protein

11

Which tumour is obesity not a risk factor for?

Renal (kidney)

12

A chest x-ray shows multiple ill-defined round opacities throughout both lung fields. This is most likely to represent...

Metastatic renal cell carcinoma

13

For a potential tumour marker, which characteristic is most important in the diagnosis of malignancy?

Sensitivity

14

What does Bcl2 do?

Evades apoptosis

15

Malignancy is defined by?

Tissue invasion

16

Radiation kills cells through interaction with?

DNA strands

17

A well circumscribed tumour protruding into the bronchus with a yellow cut surface is most likely to be a...

Carcinoid tumour

18

p53 causes cell cycle arrest between

G1 and S

19

Which tumour is most strongly associated with smoking?

Pulmonary small cell carcinoma

20

Hepatocellular carcinoma is most strongly associated with which hepato virus?

Hepatitis C

21

Which of the following is not a side effect of chemo?
Alopecia
Confusion
Neutropenic fever
Diarrhoea
Altered taste Incorrect

Confusion

22

Which of the following is not a type of cytotoxic chemotherapy?

Platinum
Alkylating agent
Taxane
Anthracycline
Telomere inhibitor

Telomere inhibitor

23

Where does lung cancer not metastasise to?

Spleen

24

Pulmonary squamous cell carcinomas are most commonly located?

centrally within the lung

25

Which tumour is associated with asbestos exposure?

Pulmonary adenocarcinoma

26

HPV promotes carcinogenesis by?

Direct mutation of p53

27

Where are cancers in lynch syndrome common?

Ascending colon

28

Carcinoma originates from?

Epithelium

29

What is the strongest risk factor for developing cholangiocarcinoma?

Primary sclerosis cholangitis

30

Gastric marginal zone lymphomas are most commonly associated with what?

H. pylori

31

What tumour originates from smooth muscle?

Leiomyoma

32

Mesothelioma is associated with which type of asbestos fibre?

Amphibole