Antibiotics, Antivirals & Antifungals Flashcards Preview

Joshua's Path > Antibiotics, Antivirals & Antifungals > Flashcards

Flashcards in Antibiotics, Antivirals & Antifungals Deck (79)
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1

Amoxicillin active against

gram positive

2

macrolides active against

gram positive - e.g erythromycin

3

cell wall inhibitors

FAPP CCTV

Flucloxacillin
amoxacillin
penicillin
piperacillin
cephalosprins
carbapenams
teicoplanin (glycopeptide)
vancomycin (glycopeptide)

4

Protein synthesis inhibitors

COMAT

chloramphenicol
oxazolidinones - linezolid
Macrolides - erythromycin
Aminoglycosides - gent
Tetracyclines (cant use in kids)

5

Inhibitors of DNA synthesis

F -aNaerobes
Fluoroquinolones (gram neg)
Nitroamidazoles - anaerobes

6

Inhibitors of RNA synthesis

Rifamycins

7

cell membrane toxins

polymixins - colistin
cyclic lipopeptides - daptomycin

8

inhibit folate metabolism

sulphonamides
diaminopyrimidines

cant use in first trimester due to fears of neural tube defects

9

do all

nitrofurans

10

an antiviral which can be used in aerosol form to prevent respiratory syncytial virus in children with heart and lung disease

ribavirin

11

What drug is used to prevent verticle transmission of HIV during pregnancy

Normal ART for the pregnant woman whether she was on treatment beforehand or not.

Viral load should be tested at 36 weeks.

If viral load is below 50 vaginal birth may continue and the baby should be given zidovudine for 4-6 weeks.

if viral load is above 50, c section with 4 hour previous zidovudine infusion, and baby recieves triple therapy for 4-6 weeks

12

Tretment for influenza

oseltamivir

13

describe the metabolism of acyclovir

uses viral thymidine kinase to make monophosphate, then cells enzymes to di and tri phosphate which is the active compnent and inhibits viral DNA polymerase

14

CMV treatment

ganciclovir

PERCH - owls eyes inclusions

Pneumonitis
Encephalitis
Retinitis
Colitis
Hepatitis

15

CMV symptoms and treatment

ganciclovir

PERCH - owls eyes inclusions

Pneumonitis
Encephalitis
Retinitis
Colitis
Hepatitis

16

valacyclovir uses

HSV VZV

17

A drug that is effective against influenza A but not influenza B

amantadine

18

Treatment for resistant or sever HSV

foscarnet or cidofovir

19

The drug which can be delivered by inhalation to treat both influenza A and B.

Zanamivir - neuraminidase inhibitor

20

Treatment of an 18 year old with Meningitis.

ceftriaxone

21

A 12 yr old boy requests treatment for widespread impetigo. He developed an urticarial rash 3 yrs ago when he was given penicillin V

erythromycin

22

Patient with an abdominal collection that contains gram –ve anaerobes.

metronidazole

23

56 year old male with endocarditis caused by VRE.

linezolid - is an oxazolidinone and is used in Vancomysin resistant enterococcus and MRSA positive. s primarily active against gram +ve

24

Severe systemic infection before cause has been identified

cefuroxime

25

legionella treatment

erythromycin - although macrolides typically have a gram positive action, they are first line in treating legionaires. fluoroquinolones are also useful.

26

treatment for sepsis, sever CAP, or HAP

cefuroxime -
may add clarythromycin to sever CAP
may add met and gent to severe sepsis

27

optochin sensitive and alpha haemolytic

strep pneumon. (viridans is also alpha haemolytic but optochin resistant)

28

what are tetracyclines good for?

intracellular pathogens

29

Name 5 classes of antifungal

PATFE
Polyenes
Azoles
Turbinofene
Flucytosine
Echinocandin

30

Name a polyene and their mechanism of action

Amphoteracin targets cell membrane integrity