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Flashcards in Immunology Deck (98)
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1

gottrens papules

dermatomyositis

2

ANA diffuse type binding

SLE(or RA)

3

ANA nucleolar binding

Systemic sclerosis

4

ANA speckled binding

Mixed connective tissue disease

5

difference between diffuse and limited systemic sclerosis?

trunk involvement in Diffuse type(scl70)

They also get pulmonary interstitial disease and more liekly to have kidney involvement

6

causes of erythema nodosum

I:strep (scarlet/rheumatic fever), yersinia, campylobacter, tb
I: Sarcoidosis. IBD, bechets,
M: pre non hodgkins lymphoma

7

caseating granuloma

TB

8

bilateral parotid enlargement

stones
HIV
mumps
sarcoidosis
alcohol

9

3 signs of sarcoidosis

hypergammagolbulinaemia
hypercalcaemia (granulomas hydroxylate vit d, causing raised calcium)
Raised ACE (abnormality of capilliaries in lung where ACE made)

10

what is osteocalcin

measure of osteoblast activity

11

what infection is assocaited with polyarteritis nodosa

Hep B

12

'palpable' purpura

vasculitis

13

finding on temporal artery biopsy with GCA

lumen narrowing
multiple grandulomas with multinuclear giant cells
lymphocytic infiltration of the tunica media

14

3 areas of pathology in granulomatosis with polyangitis

ENT
Lung
Kidney

c-anca binds to proteinase 3

15

3 areas of pathology in eosinophilic granulomatosis with polyangitis

Asthma
Eosinophilia
Vasculitis
perinuclear-anca(p-anca) binds to myeloperoxidase
(churg strauss)

16

when would you see an onion skin artery

systemic sclerosis
due to collagen deposisiton can cause hypertensive crisis due to high ACE

17

What infections are those with a neutrophil deficiency at risk of

PLACESS
pseudomonas
listeria
aspergillus
candida
e.coli
staoh aureus
serratia

18

India ink stain

cryptococcus

19

groccott stain

actinomyces

20

which drugs have an ability to disrupt biofilms

rifampicin and ciprofloxacin to a lesser extent

21

What is the most important part of managing a prosthesis infection

Removal of the prosthesis if possible, and adequate debridement. sequestration causes walling off and remain quiescent. immune system doesnt clean the prosthetic material well. including heart valves etc

22

how many people crry c dif

5%
spore forming - germinate and multiple then toxins cause damage
alcohol gel doesnt kill them. drying is what kills bacteria normally.

23

what are the indicators of a sever c dif infection

HR>90
WCC>15
indications of colitis
T>38.5
rising creatinine - renal failure diue to dehydration

ribotype 027 is severe causes more toxin release

NOT bristol stool chart

24

C.dif treatment?

Metronidazole - 400mg TDS
severe - Vancomycin 125mg QDS
Very sever with ileus or vom - both higher dose with colonic dilation

25

C.dif treatment?

Metronidazole - 400mg TDS
severe - Vancomycin 125mg QDS
Very sever with ileus or vom - both higher dose with colonic dilation

26

what does pseudomembarnous colitis look like?

wet cornflakes

27

What test would you do to confirm IgE sensitivity DURING an acute episode?

mast cell tryptase

28

Anaphylaxis management?

oxygen
adrenaline
antihistamines - chlophenamine
bronchodilators
steroids
fluids

29

What complement changes do you see in SLE

low levels of C3 and c4

30

HLA of ank spond

HLA b27