anticoagulants Flashcards Preview

MED 2042 Wks 1-5 > anticoagulants > Flashcards

Flashcards in anticoagulants Deck (8)
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1

warfarin

vit k antagonist
inhibit vit K reductase

Can be reversed with vitamin K1 administration.
antidote:Stop therapy, Vitamin K given IV or orally

INR needs to be measured.2-3 range on warfarin

Interacts (increased bleeding) with St John’s Wort.

Adverse effects of warfarin
Bleeding (common)

Contraindications
Bleeding disorders etc
Alcoholism

2

heparin

Binds to antithrombin III and activates it.
antithrombin 3 inhibits 2a, 9a, 10a, 11a, 12a

Can be reversed with protamine sulfate

IV for heparin, SC for LMWH

enoxaparin, dalteparin- LMWH

LMWH does not need aPTT monitoring.whereas unfractionated heparin does

LMWH-increase inactivation by AT III of Factor Xa,
not thrombin

3

Rivaroxaban
Apixaban

Direct Factor Xa inhibitor
Not reversible
No INR monitoring necessary

4

Dabigatran

Thrombin inhibitor
Not reversible
No INR monitoring necessary

5

aspirin

(impair platelet aggregation)
Irreversible inactivation of cyclooxygenase (COX)

low dose aspirin is anti platelet

6

Clopidogrel

(inhibit platelet binding/adhesion)

Inhibits ADP binding to platelets

7

Alteplase

helps break up clots
Recombinant form of tissue plasminogen activator

8

streptokinase

Binds to and activates plasminogen
can only be used once

helps break up clots