Haematological malignancies Flashcards Preview

MED 2042 Wks 1-5 > Haematological malignancies > Flashcards

Flashcards in Haematological malignancies Deck (12)
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1

ALL

children
risk factor-down syndrome
overproduction of immature lymphocytes-> pancytopenia

blood film: blasts

2

CLL

elderly

overproduction of mature B lymphocytes

• 1/3$cured,$1/3$stay$the$
same,$1/3$worsen$

blood film=smear cells

large, rubbery, non-tender lymph nodes

3

AML

elderly
auer rods

CML, MPN can become AML

myeloid cells can't differentiate beyond blast stage

4

CML

40-60 yrs
philadelphia gene
overproduction of mature myeloid cells

3 stages: chronic (30%)
risk factor- radiation

splenomegaly
gout (uric acid)

5

hodgkin's lymphoma

blood film: reed sternberg cells

ppl 20-40 yrs-younger

6

leukemia and lymphoma-
most are _ cell orginin

B cell

7

non hodgkin's lymphoma

elderly ppl
Usually B cells - CD20+ marker

burkitt's lymphoma- cMYC oncogene

Follicular lymphoma – BCL-2 translocation

murine splenic cells fused
with myeloma line

no reed sternberg cells

8

multiple myeloma

abnormal proliferation of plasma cells

Blood film – Rouleaux cells

High ESR > 100 (Erythrocyte sedimentation rate)

Monoclonal IgG band in serum electrophoresis

Urinalysis – Bence Jones proteins

Often tumour formed in various bones i.e. multiple

Specific signs – CRABS
! Ca2+ high (hypercalcaemia)
! Renal failure
! Anaemia
! Bony lytic lesions
! Splenomegaly

9

Myelodysplastic syndrome

elderly
Ineffective$maturation$of$all$myeloid$cells$(RBC,$WBC,$
platelets)$→pancytopaenia

10

polycythaemia rubra vera

Pruritis after
hot shower
JAK-2

11

essential thrombocytosis

overproduciton of platelets

bleeds and clots

12

myelofibrosis

blood film=tear drop cells, fragments

Massive
splenomegaly

dry tap