Anticoagulation Flashcards
(17 cards)
Heparin
Rapid but short duration of action (USAIN BOLT)- patients that have a high risk of bleeding can be stopped quickly - called ‘standard” or “heparin unfractionated”
LMWH
Low molecular weight heparin = has a longer duration of action
LMWH is proffered when?
Preferred in routine use
Which can be used during pregnancy?
On terms of anticoagulation, both LMWH and heparin can be used - because they don’t cross the placenta but heparin is preferred
Examples of Low molecular weight heparin?
Dalteparin, enoxaparin and tinzaparin
What are LMWH used for?
Used in prophylaxis of DVT
Treatment of DVT,PE, MI(generally preferred over heparin)
- its referred over heparin (unfractionated) because they are effective and have a lower risk of heparin induced thrombocytopenia
- standardard prophylactic regimen and not to much monitoring in comparison to heparin
- duration of action is longer so doses can be taken OD - making them super convenient
What are dalteparin and tinzaparin licensed for?
So its 20,000 units/ml syringe
Licensed for extended treatment of prophylaxis of VTE in patients with solid tumours
Anti-platelets - what’s Aspirin recommended for?
Secondary prevention and not primary!
What’s the difference between primary and secondary?
Primary - 1st school they’ve never had it before
Secondary- When they’ve had it already
Examples of anti-platelets
Aspirin,clopidogrel,dipyramidole, prasugurel,ticagrelor
Glycoprotein 11b/111a inhibitors -
Abciximab(monoclonal ABX), Triofiban , epifibatide
They work by decreasing platelet aggregation and inhibiting thrombus formation in arterial circulation
Who do we give ppi’s to
People at a risk of bleeding
Aspirin+clopidogrel
Increased bleeding risk
Clopidogrel indications
Prevention of artherothrombotic events eg. Iscahemic stroke, ACS
Dipyramidole
Prophylaxis of thromboembolism’s associated with prosthetic heart valves
MR Prep licensed for secondary prevention of ischaemic stroke and TIA
Dipyramidole dose
200mg BD, Taken with food
Important thing about dispensing dipyramidole
MR capsules should be dispensed only in the original container( packs contain a desiccant and any remaining caps need to be discarded 6 weeks after being opened)
