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FIRST AID CHAPTERS > Antifungal > Flashcards

Antifungal Flashcards

1
Q

Binds ERGOSTEROL and forms POReS that allow leakage of electrolytes

A

amphoTEARicin TEARS a hole in the fungal membrane by forming pores

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2
Q 
Tx: Serious, systemic mycosses.
cryptococcus
Blastomycoses
Coccidioides
Histoplasma
Candida
Mucor
A

Ampho B

Supplement K and Mg d/t altered renat tubule permeability (from nephrotoxicity)

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3
Q 
Fevers/chils
NEPHROTOXICITY (decreased by hydration)
Arrythmias
Anemia
IV phlebitis
A

SE of Ampho B

toxicity decrased by liposomal amphotericin

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4
Q

same as Ampho B but TOO TOXIC for systemic use:

swish and swallow: oral candidiaseis
topical: diaper rash

A

Nyacin

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5
Q

Inhibits DNA and RNA SYNTHESIS by conversion to 5-FU by CYTOSINE DEAMINASE

A

FLUCTYOSINE FUCKS BY DNA synthesis w/ 5-FU

systemic fungal infections (meningitis by cryptococcus)

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6
Q

Bone marrow suppression

A

Flucytosine

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7
Q

Inhibits fungal ergosterol synthesis by inhibiting cyp450 (14-alpha demethylase) that converts lanosterol> ergosterol

A

Azoles

local and less serious systemic mycoses

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8
Q

chronic supperssion of cryptococcal meningitis in AIDS pts and candida

A

Fluconazole

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9
Q

used to tx Blastomyces, coccidioides, histoplasma

A

Itraconazole

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10
Q

clotrimzole

miconazole

A

topical fungal infections

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11
Q

inhibits fungal SQUALENE EPOXIDASE to tx dermatophytes of the fingers or TOEnails

A

TErbinafine

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12
Q

GI UPset
HA
hepatotoxicity
taste distrubance

A

Terbinafine

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13
Q

inhibit cell wall cynthesis by inhibiting synthesis of B glucan

A

anidulafungin caspofungin micafungin

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14
Q

TX: invasive aspergillosis and candida

can cause FLUSING–histamine release

A

Echiniocandins

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15
Q

inhibits microtubule fxn> disrupts mitosis

deposited in KERATIN containing tissues (nails)

A

Griseofulvin

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16
Q

used for superficial infections and to inhibit the growth of dermatophytes (tinea, ringworm)

A

Griseofulvin

17
Q

TERatogenic
carcinogenic
+cytp450

A

Grisefulvin

FIRST AID CHAPTERS (17 decks)

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