Antifungals,

Question 1

Antifungal that binds to ergosterol to form pores in the membrane.

Answer 1

Amphotericin B

Question 2

Antifungal that inhibits ergosterol synthesis.

Answer 2

Azoles (ketoconazole, fluconazole, etc)

Question 3

Antifungal that inhibits squalene epoxidase and is applied topically.

Answer 3

Terbinafine

Question 4

Antifungal that interferes w/ microtubule function.

Answer 4

Griseofulvin

Question 5

How is griseofulvin taken and where does it distribute to?

Answer 5

oral; keratin-containing tissues

Question 6

Which azole crosses the BBB?

Answer 6

fluconazole

Question 7

Which antifungal inhibits DNA synthesis?

Answer 7

flucytosine

Question 8

Which antifungal inhibits cell wall synthesis by inhibiting β-glucan?

Answer 8

caspofungin

Question 9

Which antifungals can cause gynecomastia b/c they inhibit steroid hormone synthesis?

Answer 9

Azoles

Question 10

What is the difference between the method of inoculation in adult botulism and infant botulism (floppy baby syndrome)?

Answer 10

adults ingest pre-formed toxin, whereas babies ingest live spores which then replicate in the intestine

Question 11

What is the most common cause of diarrhea in infants and children under? What kind of genome does it have?

Answer 11

Rotavirus; highly segmented dsRNA genome (belongs to Reovirus family, the only one w/ a double-stranded RNA genome.)

Question 12

Which class of HIV drugs can cause hyperglycemia? Example?

Answer 12

Protease inhibitors; Ritonavir.

Think of protease cleavage of insulin from proinsulin.

Question 13

Which is the only nucleoside analog antiviral devoid of hematotoxicity?

Answer 13

Acyclovir

Question 14

What is the treatment for Chagas disease?

Answer 14

Nifurtimox