Antifungals (part 5) Flashcards
Ketaconazole is used in which type of infections?
systemic fungal infections, severe recalcitrant dermatophyte infections that are unresponsive to topical
Fluconazole is used in which type of infections?
candidiasis, vagina, cryptococcal menigitis
Itraconazole and Terbinafine are used in which type of infections?
onychomycosis
Friseofulvin is used in which type of infections? (and not)
PO only, ring worm, NOT used with candidiasis
what does yeast look like?
unicellular fungi, round, oval
how does yeast reproduce?
budding
how does mold reproduce?
branching and longitudinal extension
what does mold look like?
multicellular colonies composed of tubular structures
Dimorphism
yeast or mold depending on environmental conditions
Mycosis
presence of parasitic fungi in or on body
are azoles fungistatic or fungicidal?
static
How do azoles destroy fungi?
inhibits ergosterol synthesis which inhibits cell growth and replication
How does Griseofulvin work?
it is deposited in keratin of diseased tissue making it resistant to fungal infection, bad tissue is eventually replaced with healthy tissue
which category are azoles?
c
how often do we do LFTs with azoles?
baseline and Q2 weeks x2 months then Q1-2 months
