Antigen P&P- DCs

Question 1

DCs are directly from hematopoietic stem cells in the ________ __________

Answer 1

Bone marrow

Question 2

Newly generated DCs migrate through the body and form networks in virtually every tissue except for ?

Answer 2

Immune-privileged sites

Question 3

What cells are prominent in lymph nodes, skin, and mucosal surface-sites, where invading microbes are most likely to be encountered?

Answer 3

DCs

Question 4

What cells might develop into classical DCs when exposed to appropriate cytokines?

Answer 4

Monocytes

Question 5

What does the state of a DC depend on?

Answer 5

State of Activation

Question 6

Do DCs have a small or large cell body?

Answer 6

Small, about 13-15um

Question 7

What are the long cytoplasmic processes on DCs?

Answer 7

Dendrites

Question 8

The dendrites increase the cell surface area = __________ the efficiency of antigen trapping and maximize contact between DCs and other cell types

Answer 8

Increase

Question 9

What are the following examples of?
Plasmacytoid DC
Classical DC
Follicular DC
Langerhans cell

Answer 9

Immature DCs

Question 10

What DC has the following origin:
Bone marrow -> Lymphoid precursor -> Plasmacytic cell

Answer 10

Plasmacytoid DC

Question 11

What 3 things have the following origin:
Bone marrow -> Myeloid precursor -> Monocyte

Answer 11

Classical and Follicular DCs
Langerhan Cells

Question 12

What are mouse cDCs?

Answer 12

CD11c+CD123-

Question 13

cDCs have unique __________

Answer 13

Phenotype

Question 14

What can monocytes differentiate into depending on the cytokines and cells they encounter?

Answer 14

Macrophages and DCs

Question 15

What are specialized in taking up, processing, and presenting antigens to naive T cells?

Answer 15

Classical or conventional DCs (cDCs)

Question 16

What are long-lived cells found in blood, bone marrow, and lymphoid organs?

Answer 16

Plasmacytoid DCs

Question 17

What DC lacks a myeloid antigens, but retains some lymphoid characteristics?

Answer 17

Plasmacytoid

Question 18

What are the 2 main surface markers for Plasma- DCs

Answer 18

CD317
Siglec-H

Question 19

What serves as an early warning system for viral infections since they are rapidly activated by viral nucleic acids?

Answer 19

Plasma DCs

Question 20

Do Plasma DCs increase or decrease during infection?

Answer 20

Increase

Question 21

Plasma DCs respond to viruses by synthesizing a large amount of type _ interferons

Answer 21

1

Question 22

Besides type I interferons, plasma DCs are also major produces for type __ interferons

Answer 22

3

Question 23

Since Plasma DCs secrete large amount of type 1 interferons (IFN- alphas), what other types of cells do they activate?

Answer 23

Natural Killer (NK) cells

Question 24

What type of granules do Langerhan cells have?

Answer 24

Birbeck granules

Question 25

Long dendrites form an extensive network for antigen _________

Answer 25

Capture

Question 26

What type of DCs are found in the germinal centers of the spleen, lymph nodes, and Peyer’s patches? Also around localized infection sites and chronic inflammatory rxns?

Answer 26

Follicular DCs (fDCs)

Question 27

What type of DCs are essential for antibody production and the development of B cell memory?

Answer 27

fDCs

Question 28

What type of DCs capture antigens by phagocytosis, by pinocytosis, and by binding to cell surface receptors?

Answer 28

Immature DCs

Question 29

Immature DCs kill invaders by mounting a ___________ ______

Answer 29

Respiratory burst

Question 30

Immature DCs -pH within phagosomes are alkaline. Antigens are not completely degraded, but preserved for presentation by MHC __ molecules

Answer 30

2

Question 31

What DCs are in response to IL-1, TNF-alpha, PAMPs, and DAMPs?

Answer 31

Activated (mature) DCs

Question 32

What has the main function to present antigens to T cells, NOT capture antigens?

Answer 32

Activated (mature) DCs

Question 33

For Activated (mature) DCs- Cell surface expressions of MHC molecules and ___________ molecules increase

Answer 33

Costimulatory

Question 34

Where do activated (mature) DCs migrate to?

Answer 34

Draining lymph nodes

Question 35

Mature dendritic cells= express increases level of surface ____ and ___________ molecules

Answer 35

MHC Costimulatory