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Immunology Exam 2 > Antigen P&P- DCs > Flashcards

Antigen P&P- DCs Flashcards

1
Q

DCs are directly from hematopoietic stem cells in the ________ __________

A

Bone marrow

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2
Q

Newly generated DCs migrate through the body and form networks in virtually every tissue except for ?

A

Immune-privileged sites

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3
Q

What cells are prominent in lymph nodes, skin, and mucosal surface-sites, where invading microbes are most likely to be encountered?

A

DCs

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4
Q

What cells might develop into classical DCs when exposed to appropriate cytokines?

A

Monocytes

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5
Q

What does the state of a DC depend on?

A

State of Activation

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6
Q

Do DCs have a small or large cell body?

A

Small, about 13-15um

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7
Q

What are the long cytoplasmic processes on DCs?

A

Dendrites

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8
Q

The dendrites increase the cell surface area = __________ the efficiency of antigen trapping and maximize contact between DCs and other cell types

A

Increase

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9
Q

What are the following examples of?
Plasmacytoid DC
Classical DC
Follicular DC
Langerhans cell

A

Immature DCs

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10
Q

What DC has the following origin:
Bone marrow -> Lymphoid precursor -> Plasmacytic cell

A

Plasmacytoid DC

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11
Q

What 3 things have the following origin:
Bone marrow -> Myeloid precursor -> Monocyte

A

Classical and Follicular DCs
Langerhan Cells

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12
Q

What are mouse cDCs?

A

CD11c+CD123-

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13
Q

cDCs have unique __________

A

Phenotype

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14
Q

What can monocytes differentiate into depending on the cytokines and cells they encounter?

A

Macrophages and DCs

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15
Q

What are specialized in taking up, processing, and presenting antigens to naive T cells?

A

Classical or conventional DCs (cDCs)

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16
Q

What are long-lived cells found in blood, bone marrow, and lymphoid organs?

A

Plasmacytoid DCs

17
Q

What DC lacks a myeloid antigens, but retains some lymphoid characteristics?

A

Plasmacytoid

18
Q

What are the 2 main surface markers for Plasma- DCs

A

CD317
Siglec-H

19
Q

What serves as an early warning system for viral infections since they are rapidly activated by viral nucleic acids?

A

Plasma DCs

20
Q

Do Plasma DCs increase or decrease during infection?

A

Increase

21
Q

Plasma DCs respond to viruses by synthesizing a large amount of type _ interferons

A

1

22
Q

Besides type I interferons, plasma DCs are also major produces for type __ interferons

A

3

23
Q

Since Plasma DCs secrete large amount of type 1 interferons (IFN- alphas), what other types of cells do they activate?

A

Natural Killer (NK) cells

24
Q

What type of granules do Langerhan cells have?

A

Birbeck granules

25
Q

Long dendrites form an extensive network for antigen _________

A

Capture

26
Q

What type of DCs are found in the germinal centers of the spleen, lymph nodes, and Peyer’s patches? Also around localized infection sites and chronic inflammatory rxns?

A

Follicular DCs (fDCs)

27
Q

What type of DCs are essential for antibody production and the development of B cell memory?

A

fDCs

28
Q

What type of DCs capture antigens by phagocytosis, by pinocytosis, and by binding to cell surface receptors?

A

Immature DCs

29
Q

Immature DCs kill invaders by mounting a ___________ ______

A

Respiratory burst

30
Q

Immature DCs -pH within phagosomes are alkaline. Antigens are not completely degraded, but preserved for presentation by MHC __ molecules

A

2

31
Q

What DCs are in response to IL-1, TNF-alpha, PAMPs, and DAMPs?

A

Activated (mature) DCs

32
Q

What has the main function to present antigens to T cells, NOT capture antigens?

A

Activated (mature) DCs

33
Q

For Activated (mature) DCs-
Cell surface expressions of MHC molecules and ___________ molecules increase

A

Costimulatory

34
Q

Where do activated (mature) DCs migrate to?

A

Draining lymph nodes

35
Q

Mature dendritic cells= express increases level of surface ____ and ___________ molecules

A

MHC
Costimulatory

Immunology Exam 2 (25 decks)

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