antigens and MHC

Question 1

terms to describe an antigen

occur in unrelated animal and plant species, but they share the same structure

Answer 1

heterogenetic/heterophilic antigen

Question 2

antigen

• are incomplete/partial antigens
• gives the antigen its antibody provoking abilities
• they cannot induce immune response alone
• antigens will become antigen if it binds to it
• low molecular weight
• antigenic

Answer 2

hapten

Question 3

types of adjuvants

Answer 3

• aluminum and calcium salts
• freund’s adjuvant
• lipopolysaccharide/endotoxins
• squalene

Question 4

classification

carrier and hapten are present

Answer 4

complete antigen

Question 5

• thymic dependent produces:
• thymic independent produces:

Answer 5

• IgG
• IgM

Question 6

• substances that induce mitosis
• can be considered “mimics of antigens”

Answer 6

mitogen

Question 7

terms to describe an antigen

• “twin”
• between genetically identical individual
• isograft

Answer 7

syngeneic antigen

Question 8

antigenic determinants

• it is seen on antigen:
• it is seen on antibodies:

Answer 8

• epitope
• paratope

Question 9

B cell or T cell Mitogens

• concanavalin A (Con A)
• phytohemagglutins

Answer 9

T cell mitogens

Question 10

chromosome 6: CLASS I, CLASS II or CLASS III

• C4B
• C4A
• C2
• TNF

Answer 10

CLASS III

Question 11

attached to the antigen, and would fit to the antigen binding site on our antibodies

Answer 11

epitope

Question 12

B cell or T cell Mitogens

• lipopolysaccharide
• protein A
• anti-immunoglobulin

Answer 12

B cell mitogens

Question 13

any agent capable of inducing an immune response

Answer 13

immunogen

Question 14

terms to describe an antigen

• “sibling”
• between different individuals with same species
• homograft/allograft

Answer 14

allogenic/homologous antigen

Question 15

2 or more compounds that has a degree of dissimilarity, but share antigenic determinants

Answer 15

cross reactivity

Question 16

classification

either the carrier or hapten is present

Answer 16

incomplete antigen

Question 17

kinds of antigen

a particulate antigen which when reacted with its antibody, results in the appearance of clumps/agglutination

Answer 17

agglutinogen

Question 18

kinds of antigen

acted upon by allergenic antibodies in allergic reactions

Answer 18

allergens/anaphylactogens

Question 19

MHC cell distribution: CLASS I, II, or III

on B cells antigen presenting cells

Answer 19

CLASS II

Question 20

determinants common to several HLA molecules each of which additionally bears a distant HLA private antigen

Answer 20

HLA public antigens

Question 21

MHC cell distribution: CLASS I, II, or III

found on all nucleated cells

Answer 21

CLASS I

Question 22

kinds of antigen

a soluble antigen which when reacted with antibody results in precipitation pr setting out of antigen

Answer 22

precipitinogen

Question 23

chromosome 6: CLASS I, CLASS II or CLASS III

HLA-A,B,C

Answer 23

CLASS I

Question 24

terms to describe an antigen

• comes from self
• same individual
• autograft

Answer 24

autologous antigen

Question 25

# chemical composition of antigen - most are HAPTENS - do not posses sufficient chemical diversity

Answer 25

polysaccharide

Question 26

# kinds of antigen neutralized by antitoxin

Answer 26

toxin

Question 27

any agent capable of binding to components of immune response

Answer 27

antigen

Question 28

# chromosome 6: CLASS I, CLASS II or CLASS III - DP region: beta-1,2; alpha-1,2 - DQ region: beta-1,2,3; alpha-1,2 - DR region: (4)beta, alpha

Answer 28

CLASS II

Question 29

property to induce a detectable immune response

Answer 29

immunogenicity

Question 30

he, a french scientist, gave the name HLA (human leukocyte antigen)

Answer 30

Dausset

Question 31

# chemical composition - most immunogenic (strongest) - high no. of epitopes - high no. of antibody

Answer 31

protein

Question 33

- found on all nucleated cells in the body - plays a pivotal role on both humoral and cellular immunity - MAIN FXN: brings antigen to the cell surface for recognition by T cellls

Answer 33

MHC molecules

Question 34

# chemical composition of antigen - immunogens - best illustrated by RBC blood group antigens - HLA antigen

Answer 34

glycoprotein

Question 35

genes coding for MHC molecules are found on in the (?)

Answer 35

short arm of chromosome 6

Question 36

all (?) are antigenic whereas (?) are not necessarily immunogenic

Answer 36

- immunogens - antigens

Question 37

genes controlling expression of a large group of proteins

Answer 37

MHC (major histocompatibility complex)

Question 38

# antigen - protein which gives the hapten the required size - high molecular weight - immunogenic - can cause production of antibody

Answer 38

carrier

Question 39

# terms to describe an antigen - "animal" - between different individuals of different species - xenograft

Answer 39

xenogenic/heterologous

Question 40

substances administered with an antigen that enhances the immune response

Answer 40

adjuvants

Question 41

# antigenic size - non immunogenic: - reasonable/potent immunogenic: - good immunogen: - excellent immunogen:

Answer 41

- <5,000 da - >10,000 da - 40,000 da (albumin) - >1,000,000 da (hemocyanin)

Question 42

combined B and T cell mitogens:

Answer 42

- pokeweed mitogen - lectins

Question 43

HLA antigens found on single molecule (and no other)

Answer 43

HLA private antigens