Antigens & Receptors Flashcards Preview

Immunology > Antigens & Receptors > Flashcards

Flashcards in Antigens & Receptors Deck (10)
Loading flashcards...
1

Immunogens

Molecules that elicit an immune response

2

Stages of the immune response

1. Recognition phase - innate recognition
2. Activation phase - B/T-cell activation
3. Effector phase - pathogen is destroyed

3

Secondary lymphoid tissue

Secondary lymphoid tissue is an important part of antigen recognition

It facilitates encounters between B/T cells and antigens

Lymph nodes = tissue infections
Spleen = blood infections

4

Antigen definition

Any substance that binds to specific receptors on lymphocytes

5

Epitope definition

The part of the antigen that binds to receptors

6

Hapten definition

A small molecule that can act as an epitope but cannot elicit an immune response

7

Immunogenicity

Immunogenicity describes the ability of an antigen to elicit an immune response

A larger molecule with more differences to self-proteins that enters via the subcutaneous route will be the most immunogenic

8

Adjuvants

Adjuvants enhance the immune response to an antigen to make it more immunogenic

They are not natural components but are added to vaccines to improve success

-Freund's adjuvant
-Alum

9

B-cell receptors

B-cells bind to native antigen in solution

They recognise the 3D conformation of the antigen via the B-cell receptor

10

T-cell receptors

T-cells bind linear arrays of antigen

The antigen must first be broken down by antigen-presenting cells to chains of approximately 9 amino acids