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Flashcards in Innate Immunity Deck (11)
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1

Innate immune system

The non-specific arm of the immune system

The first line of defence against pathogens & is ready from birth

2

Innate immune cells

There is some overlap between innate and adaptive immune cells

-Neutrophils
-Monocytes/ macrophages
-B-cells
-Mast cells
-Eosinophils
-Dendritic cells
-NK cells
-NKT cells
-Innate lymphoid cells

3

Anatomical barriers of the innate immune system

The innate immune system includes all physical barriers to infection

-Skin
-Mucosal surfaces
-Coughing
-Flow of urine

4

Physiological barriers of the innate immune system

The physiology of the human body can inhibit microbial growth

-Body temperature (fever)
-pH
-Chemical mediators

5

Innate lymphoid cells

Have no T-cell receptor and do not have PRRs

Are activated by local mediators (except NK cells)

Found mostly in the skin and mucosa

There are 3 groups of innate lymphoid cells

6

Innate lymphoid cells- group 1

Includes NK cells and ILC1 cells

Secrete pro-inflammatory cytokines IFNy and TNFa

NK cells = Immunity to intracellular pathogens

ILC1 cells = immunity to extracellular pathogens

7

Innate lymphoid cells- group 2

Includes ILC2 cells

Secrete cytokines that activate eosinophils

ILC2 cells = immunity to worms & promote wound healing

8

Innate lymphoid cells- group 3

Includes ILC3 cells

Secrete regulatory cytokines

ILC3 cells = play a role in lymphoid tissue development and intestinal health
immunity to extacellular bacteria and fungi

9

Natural killer T-cells

Have a T-cell receptor but do not recognise presented antigen

Recognise CD1 and lipid antigens during innate immunity

Secrete pro-inflammatory cytokines

10

y/d T-cells

Recognise bacterial antigens

Known to phagocytose

11

B1 cells

A sub-group of B-cells that express CD5

Produce low-affinity IgM antibodies against bacterial antigens

Important in neonate immunity