T-cell Effector Functions Flashcards Preview

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Flashcards in T-cell Effector Functions Deck (5)
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1

T-cell migration

T-cell activation occurs in the secondary lymph organs but the infection is often occurs in the periphery

To guide the T-cell to the infection side, a guidance system of cytokines and chemokines is in place

Cytokines = upregulate adhesion molecule expression on the endothelium

Chemokines = attracts cells to the site

2

CD8 T-cells

CD8 T-cells are cytotoxic

Their killing is very specific so they must have cell-cell contact

Adjacent cells are unaffected by the killing of the target cell

3

Granzyme/perforin killing

Granules are released onto the target via the immunological synapse

Perforin creates pores in the target cell, this then allows granzyme entry

Granzyme activates the caspase cascade

4

Contraction

As the antigen is cleared, the stimulus for co-stimulation subsides and T-cell responses decline

Homeostasis is restored

5

Memory

Some progeny develop into long-lived quiescent cells

Memory cells are responsible for the accelerated and enhanced secondary immune response