Mucosal immunity Flashcards
1
Q
Physical barriers in mucosal immunity
A
The intestinal mucosa provides a semi-permeable barrier made up of compacted glycoproteins, anti-microbial peptides and secretory IgA
2
Q
Innate immunity in the mucosa
A
Dendritic cells, macrophages and ILCs are located close to the epithelium
They are attracted to the intestinal mucosa by the chemokine MIP3a
Dendritic cells reach past tight junctions to sample the intestinal lumen
3
Q
Adaptive immunity in the mucosa
A
IgA, Th17 and Treg cells are notably found in the mucosa
Peyer’s patches are lymphoid aggregates in the small intestine
