Antimicrobial Chemotherapy Flashcards Preview

Yr1 -S1 - Principles of Disease > Antimicrobial Chemotherapy > Flashcards

Flashcards in Antimicrobial Chemotherapy Deck (48):
1

bactericidal

antimicrobial that kills bacteria

(penicillin's)

2

bacteriostatic

antimicrobial inhibits growth of bacteria

3

sensitive

if organism is able to be inhibited or killed by the antimicrobial

4

MBC

Minimal bactericidal concentration

5

Minimal bactericidal concentration

minimum concentration of antimicrobial needed to kill a given organism

6

MIC

Minimal inhibitory concentration

7

Minimal inhibitory concentration

minimum concentration of antimicrobial needed to inhibit growth of a given organism

8

parenteral

administered intravenously

9

Antibiotics may inhibit/ kill bacteria in three ways:

inhibition of cell wall synthesis

inhibition of nucleic acid synthesis

inhibition of protein synthesis

10

Antibiotics that inhibit cell wall synthesis

Beta lactams


(penicillin and cephalosporins)

11

beta lactams

disrupt peptidoglycan synthesis by inhibiting penicillin binding proteins PBPs!

12

Glycopeptides only act on

gram positive organisms

13

Glycopeptides are administered

by IV

14

Glycopeptides act on cell wall synthesis before

beta lactams

inhibiting assembly of peptidoglycan precursor

15

Antibiotic that inhibit protein synthesis

aminoglycosides

macrolides

tetracycline

oxazolidinones

cyclic lipopeptide

16

E.coli is gram....

negative

17

inhibitors of nucleic acid synthesis involve the inhibition of different steps in

purine synthesis

18

Inhibitors of nucleic acid synthesis

co-trimoxazole

fluoroquinolones

19

Trimethoprim

treats UTI

20

streptococci is always resistant to...

aminoglycosides

21

Gram negative organisms are always resistant to

vancomycin

22

E.coli is resistant to

ampicillin

23

two ways in which resistance is acquired

spontaneous

spread of resistance

24

beta lactamases are bacterial enzymes which cleave the...

beta lactam ring of the antibiotic

they thus render it inactive

25

most staphylococcus aureus produce

beta lactamase

26

two ways to combat beta lactamase

add another antibiotic

modify the antibiotic

27

Flucloxacillin is

beta lactamase resistant

28

Flucloxacillin can treat

staphylococcal infections

29

benzyl penicillin can treat

gram positive organisms

30

amoxicillin, ampicillin treat

gram negative

31

co-amoxiclav

beta lactamase producing coliforms

32

aminoglycosides treat

gram negative organisms

33

Gentamicin

cheap and most commonly used

treated gram negative

e.coli

34

Marcolides treat

gram positive

35

Quinolones treat nearly all

gram negative

36

C. difficile is gram

positive

37

thrush from

candida albicans

38

Polyenes bind to

ergosterol

39

ergosterol is present in

fungal cell wall but not bacterial cell wall

40

amphotericin B

treats serious fungal infections

41

used to treat HIV

saquinavir

42

trimethoprim

treats purine synthesis

43

UTI

nitrofurantoin

44

MRSA treated with

vancomycin

45

nyastatin

fungal infections

vagina, oesophageal

46

Azoles function

inhibit ergosterol synthesis

47

azoles treat

yeast infections

48

Aciclovir is an

Anti-herpes drug