Chronic Inflammation Flashcards Preview

Yr1 -S1 - Principles of Disease > Chronic Inflammation > Flashcards

Flashcards in Chronic Inflammation Deck (32):
1

cell population in inflammation is mostly

lymphocytes
plasma cells
macrophages
fibroblasts

2

clinical presentations can be

loss of function

malaise and weight loss

3

when do we see chronic inflammation?

arising from acute inflammation


arising as a primary lesion

4

Granulation tissues us a characteristic of...

organisation

results in healing and repair

leads to fibrosis and formation of a scar

5

Granulation tissue mechanism

capillaries grow into inflammatory mass


access plasma proteins

macrophages move from blood to tissue

fibroblasts lay down collagen to repair damaged tissue

collagen replaces inflammatory exudate

6

fibroblasts lay down ........... to repair damaged tissue

collagen

7

macrophages move from

blood to tissue

8

collagen replaces

inflammatory exudate

9

Products of granulation tissue

fibrous tissue (scar)

fibrosis as a problem

chronic inflammation

10

fibrosis

the formation of excess fibrous connective tissue in an organ or tissue to repair

11

autoantibodies directed against own cell components (AUTOANTIGENS)

disease is called?

autoimmune disease

12

tissue components

granulation tissue

collagen

13

two types of lymphocyte

T cell

B cell

14

Lymphocyte 2 main functions

immune response

immune memory

15

Lymphocytes are part of the ............ system

immune

16

Plasma cell is a

differentiated B cell

17

plasma cells produces

antibodies

18

B cells differentiate into

plasma cells

19

T cells produce

cytokines

interferons

20

Cytokines attract, hold and activate

macrophages

21

interferons have

antiviral effects

22

NK cells destroy

antigens and cells

23

Macrophage (phagocyte)role in the immune system is an

antigen presenting cell

24

Macrophages remove

debris

25

macrophages take over from

neutrophils

26

Fibroblasts make and assemble

collagen

27

Granulomatous inflammation is stimulated by

indigestible antigen

(body cannot get rid of it)

28

Granulomas

aggregates of epithelioid macrophages in tissues

29

A giant cell

is a mass formed by the union of several distinct cells (usually macrophages), often forming a granuloma

30

4 types of giant cells

langhans
foreign body
silicone
warthin-finkeldy

31

Infectious granulomatous diseases

tuberculosis
leprosy
syphilis

32

sequence of events

acute inflammation

organisation

granulation tissue

macrophages remove debris